Large analysis defines predictors of late AMD risk
The predictors of development of late age-related macular degeneration are based on age, sex, 26 single nucleotide polymorphisms, smoking, body mass index and early AMD phenotype, according to a prediction model.
An analysis of the Three Continent AMD Consortium included three population-based studies, the Rotterdam Study, the Beaver Dam Eye Study and the Blue Mountains Eye Study, which comprised 10,106 participants who were analyzed using fundus photographs, genotype data and follow-up data. Those with late AMD at baseline were excluded.
Subjects were followed for a median of 11.1 months, consisting of four to five visits.
Three hundred sixty-three subjects developed incident late AMD and 3,378 subjects developed early AMD, while 6,365 subjects did not develop any form of AMD.
“Our prediction model is robust and distinguishes well between those who will develop late AMD and those who will not. Estimated risks were lower in these population-based studies than in previous case-control studies,” the study authors said.
Furthermore, the apparent risk of incident AMD may encourage individuals to modify their lifestyle to prevent late AMD, the authors said.
Disclosure: The study authors have no relevant financial disclosures.