October 14, 2013
1 min read

Asymmetry parameters identify early primary open-angle glaucoma

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Asymmetry parameters can be useful in identifying early primary open-angle glaucoma, according to a study.

The prospective, cross-sectional cohort study included both eyes of 50 patients with early primary open-angle glaucoma and 50 control subjects. All eyes underwent measurements of macular thickness and retinal nerve fiber layer thickness (RNFL) using spectral-domain optical coherence tomography (Spectralis, Heidelberg Engineering).

The study authors reported that intereye macular thickness asymmetry showed the highest diagnostic sensitivity (88% at 80% specificity; 83% at 95% specificity), succeeded by total RNFL thickness (88% at 80% specificity; 75% at 95% specificity).

The three best parameters that were independently associated with identifying early primary open-angle glaucoma were the total RNFL thickness, intraeye difference in macular thickness and intereye difference in RNFL thickness.

“Specifically, our results suggest that glaucoma is likely when intereye macular thickness asymmetry is 5 µm or more, when intraeye macular thickness asymmetry is 9 µm or more, when intereye RNFL thickness asymmetry is 9 µm or more, and when total RNFL thickness is 78 µm or less,” the authors said.

Disclosure: The study authors have no relevant financial disclosures.