September 16, 2013
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Dilute brimonidine reduces subconjunctival hemorrhage, improves comfort after LASIK

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Administration of dilute brimonidine before LASIK reduced subconjunctival hemorrhage and injection while improving patient comfort postoperatively, a study found.

The randomized, double-masked, prospective study included 360 eyes of 180 patients that underwent administration of topical dilute brimonidine or naphazoline/pheniramine in one eye per patient compared with a control in the fellow eye (Systane Ultra, Alcon) preceding LASIK.

Eyes treated with dilute brimonidine had significantly reduced outcomes of discomfort, subconjunctival hemorrhage and injection at 1 hour and 1 day postoperative evaluations.

Refloats were required for mild-flap edge wrinkling in three of the dilute brimondide eyes and one naphazoline/pheniramine eye with no cases in the control group. The difference was not statistically significant, the study authors said.

“These potential consequences are important to consider given that we are seeking to increase patient comfort and minimize the social and psychological impact of subconjunctival hemorrhage,” they said.

Disclosure: The study authors report no relevant financial disclosures.