September 16, 2013
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Corneal hysteresis strongly associated with glaucoma progression, study finds

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Corneal hysteresis correlated significantly with an elevated risk of glaucoma progression, according to a study.

“Eyes with lower hysteresis had faster rates of visual field loss than those with higher hysteresis,” the study authors said. “An eye with a more deformable cornea could have an optic disc that is more susceptible to IOP damage.”

The prospective cohort study included 114 eyes of 68 patients with glaucoma. The Ocular Response Analyzer (ORA) was used to measure corneal hysteresis (CH) at baseline. The Visual Field Index (VFI) was used to gauge the rate of visual field change.

Investigators used statistical analysis to determine relationships between IOP, rate of glaucoma progression and CH. Average follow-up was 4 years.

Using only corneal hysteresis and time as variables, the authors found that each 1 mm Hg reduction in CH correlated with an annual 0.25% acceleration in rate of VFI decline (P < .001).

Results showed a statistically significant relationship between central corneal thickness (CCT) and CH (P < .001).

Eyes with high IOP and low CH had an increased risk of rapid disease progression.

Disclosure: The study was supported in part by grants from the National Eye Institute, CAPES, Research to Prevent Blindness. Alcon, Allergan, Pfizer, Merck and Santen provided grant funding for medications. See the study for a full list of all authors’ relevant financial disclosures.