Graves' ophthalmopathy linked to dry eye disease, corneal sensitivity loss
Early-stage Graves' ophthalmopathy was associated with clinically significant dry eye disease and reduced corneal sensitivity, according to a study.
“[Graves’ disease] should be considered in the differential diagnosis for patients presenting with dry eyes and warrants further investigation, even in the absence of other clinical symptoms,” the study authors said.
The study included 52 eyes of 26 patients diagnosed with early Graves' ophthalmopathy (GO). A control group comprised 74 eyes of 37 healthy subjects. All patients underwent a complete ocular surface examination and diagnosis of Graves’ disease.
Study results showed that ocular surface dryness was identified in 67.8% of patients with early GO and 13.5% of controls; the between-group difference was statistically significant (P < .001).
Corneal sensitivity was significantly lower in patients with early GO than in controls (P < .05).
Tear film breakup time was significantly lower in the study group than in controls (P < .001).
Disclosure: The study authors report no relevant financial disclosures.