September 04, 2013
1 min read

AREDS shows markedly reduced AMD progression, moderate vision loss at 10 years

You've successfully added to your alerts. You will receive an email when new content is published.

Click Here to Manage Email Alerts

We were unable to process your request. Please try again later. If you continue to have this issue please contact

Nutritional supplements were associated with a reduced risk of progressive neovascular age-related macular degeneration, according to the Age-Related Eye Disease Study; however, the supplements did not reduce the risk of geographic atrophy.

AREDS included 4,757 patients; 3,549 patients took part in an epidemiologic follow-up study, which reported 10-year outcomes. The study featured a formulation comprising 500 mg of vitamin C, 400 IU of vitamin E, 15 mg of beta-carotene, 80 mg of zinc and 2 mg of copper.

Patients participating in AREDS were randomly assigned to one of four treatment groups: placebo, zinc, antioxidants or antioxidants plus zinc.

Patients were also assigned to one of four categories: category 1 (no AMD with small drusen); category 2 (early AMD with small or intermediate drusen, pigment abnormalities or a combination of both); category 3 (no advanced AMD but one or more large drusen, extensive area of intermediate drusen or geographic atrophy not involving the center of the macula); and category 4 (advanced AMD, central geographic atrophy or neovascular AMD in one eye).

Patients assigned to the placebo group in categories 3 and 4 had a significantly higher risk of developing advanced AMD or neovascular AMD than those assigned to the AREDS formulation (P < .001).

The risk of developing central geographic atrophy was not reduced significantly. Moderate vision loss was reduced significantly (P = .002).

Disclosure: The study was supported in part by the National Eye Institute/National Institutes of Health. The study authors report no relevant financial disclosures.