Triamcinolone acetonide safer than infracyanine green in macular hole surgery
Vitrectomy and internal limiting membrane peeling with triamcinolone or infracyanine green staining improved vision in patients with idiopathic macular holes, according to a study.
However, infracyanine green staining was found to damage the photoreceptors, as evidenced by a reduction of focal electroretinogram (fERG) first harmonic amplitude; no toxic effects were associated with triamcinolone acetonide, the study authors said.
Investigators prospectively evaluated 30 eyes of 30 patients who underwent pars plana vitrectomy and internal limiting membrane (ILM) peeling to repair idiopathic macular holes.
Triamcinolone acetonide was used to stain the ILM in 15 eyes and infracyanine green dye was used in the remaining 15 eyes.
Best corrected visual acuity, microperimetry and fERG were assessed preoperatively and for 12 months postoperatively.
The amplitude of foveal fERG was significantly higher in the triamcinolone acetonide group than in the infracyanine green group at 12 months (P = .02). The amplitude of macular fERG was significantly higher in the triamcinolone acetonide group than in the infracyanine green group (P = .03).
Macular hole closure was successful and visual acuity improved in both groups (P = .0001).
Disclosure: The study authors report no relevant financial disclosures.