August 12, 2013
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Oral steroids, intravenous antibiotics may resolve inflammation with low risk in orbital cellulitis patients

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Oral corticosteroids along with intravenous antibiotics can potentially reduce inflammation with a low risk of infection for patients with orbital cellulitis, according to a study.

The prospective, comparative, single-masked interventional clinical study involved 21 patients with orbital cellulitis separated into two groups. Group one comprised seven patients who received standard intravenous antibiotics, and group two comprised 14 patients who received intravenous antibiotics and adjuvant steroids.

Data were evaluated between the two groups for signs and symptoms, duration of antibiotics, length of hospital stay and sequelae of disease.

Group two had earlier resolution of inflammation in periorbital edema, conjunctival chemosis and pain (P = .002 at day 7, P < .001 at day 10 and P = .012 at day 7, respectively). Vision in group two was 0.2 logMAR earlier than group one, and durations of antibiotics and hospital stay were less in group two. No patients from group two had recurrence or spread of infection.

Disclosure: The study authors report no relevant financial disclosures.