July 26, 2013
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Prostaglandin analogue may be beneficial in glaucomatous eyes with myopic disc

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In glaucoma patients with a myopic disc, topical tafluprost reduced IOP and increased mean blur rate in the optic nerve head, according to a study.

The study included 48 eyes of 24 subjects with a myopic disc; 28 eyes were diagnosed with normal tension glaucoma and 20 eyes did not have glaucoma. In each subject, tafluprost was administered in the eye with the higher IOP or worse visual field loss, and the other eye served as the control.

The increase in optic nerve head blood flow in eyes treated with tafluprost was significant at 60 minutes, 90 minutes and 120 minutes after instillation (P = .008, P < .001 and P < .001, respectively). Treatment eyes with glaucoma had a significant optic nerve head blood flow increase at 90 minutes and 120 minutes (P = .025 and P = .049, respectively).

The decrease in IOP in eyes treated with tafluprost was significant at 60 minutes, 90 minutes and 120 minutes after instillation (P = .001, P = .002, P = .007, respectively). Treatment eyes with glaucoma had a significant decrease in IOP at 60 minutes to 90 minutes (P = .001 and P = .023, respectively).

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