July 26, 2013
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Integrity of outer retinal structures portends visual acuity after AMD treatment, scarring

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The integrity of foveal outer retinal structures and baseline visual acuity strongly predicted final visual acuity in patients with subfoveal scarring after treatment of wet age-related macular degeneration, according to a study.

The retrospective study included 79 eyes of 64 patients who developed subfoveal scarring after wet AMD treatment.

Investigators assessed logMAR best corrected visual acuity, IOP and slit lamp biomicroscopy. Spectral-domain optical coherence tomography and fluorescein angiography were used to evaluate inner segment/outer segment junction, external limiting membrane, central macular thickness, subfoveal scar thickness, subretinal scar area and proximity of the retina to intact outer structures of the fovea.

There were statistically significant associations between final BCVA and distance between the fovea and the nearest retina with intact inner segment/outer segment junction and external limiting membrane (P < .005). There was also a significant correlation between final BCVA and scar area (P = .018).

Baseline BCVA and distance between the fovea and nearest retina with intact outer structures were the best predictors of final BCVA.

Results showed no associations between final BCVA and scar thickness or central macular thickness, the authors said.