July 19, 2013
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Normal autofluorescence heralds improved VA after surgical macular hole closure

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Fundus autofluorescence findings correlated with visual improvement and photoreceptor status in eyes that underwent surgical macular hole closure, according to a study.

The retrospective study included 26 eyes with surgically closed macular holes that underwent 23-gauge, three-port vitrectomy with internal limiting membrane peeling.

Investigators analyzed the association between foveal fundus autofluorescence and visual acuity. Spectral-domain optical coherence tomography was used to examine the foveal microstructure.

Nine eyes had normal autofluorescence (NAF) and 17 eyes had increased autofluorescence (IAF).

Study results at 1 month showed that logMar best corrected visual acuity was 0.59 in the NAF group and 0.91 in the IAF group; the difference was statistically significant (P = .044). BCVA tended to be higher in the NAF group at 6 months.

Photoreceptor external limiting membrane was restored in eight NAF eyes (89%) and four IAF eyes (24%) at 1 month (P = .001). At 6 months, the photoreceptor external limiting membrane was restored in all NAF eyes and in 11 IAF eyes (65%, P = .042).