June 20, 2013
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Combination immunotherapy controls inflammation in birdshot retinochoroidopathy

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Cyclosporine A and mycophenolate mofetil controlled inflammation in the treatment of birdshot retinochoroidopathy, according to a study.

The retrospective study included 98 eyes of 49 patients with birdshot retinochoroidopathy.

Initial dosages were 3 mg per kg of weight for cyclosporine A and 1 g twice daily for mycophenolate mofetil. Dosages were changed in patients who showed no improvement or experienced adverse events. The drugs were discontinued for at least 2 weeks in patients with side effects or drug toxicity until symptoms or laboratory abnormalities resolved.

There were statistically significant reductions in vitreous inflammation scores in right eyes (P < .001) and left eyes (P = .001) at 1 year. Inflammation was controlled successfully in 31 of 46 patients (67.4%) at 1 year.

Angiographic leakage of retinal vessels decreased significantly (P = .0039). There was no significant decrease in cystoid macular edema.

Changes in logMAR best corrected visual acuity were insignificant at 1 year.