Cross-linking for keratoconus improves long-term visual acuity, refraction, topography
Corneal collagen cross-linking successfully halted the progression of keratoconus for up to 4 years or more, according to a study.
Investigators analyzed 30 patients with early to moderate keratoconus who underwent unilateral corneal collagen cross-linking with riboflavin and ultraviolet A 4 years to 6 years previously. Mean age at the time of cross-linking was 26.3 years; the mean interval between cross-linking and clinical evaluation was 53.3 months.
From before treatment out to 4 years to 6 years, mean spherical equivalent refractive error and corrected distance visual acuity improved significantly; mean simulated keratometry, cone apex power, root mean square, coma, secondary astigmatism and pentafoil decreased significantly.
From 1-year results out to 4 years to 6 years, mean simulated keratometry, cone apex power, root mean square, coma and secondary astigmatism decreased significantly; central pachymetry increased significantly.
No treated eyes had progression of keratoconus and none lost more than one line of corrected distance visual acuity; keratoconus progressed in seven untreated fellow eyes, the authors said.