May 30, 2013
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Platelet-rich plasma drops may not affect corneal sensitivity recovery after LASIK

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Topical application of platelet-rich plasma does not appear to have a positive effect on corneal sensitivity recovery after LASIK, according to a study.

The randomized, controlled, masked prospective study included 108 eyes of 54 patients who underwent LASIK for myopia or myopic astigmatism.

Eyes in the control group received saline drops six times a day, and fellow eyes in the treatment group received platelet-rich plasma drops every 5 hours during the daytime. Administration of treatment was 6 weeks for both groups.

Both groups showed significant differences in corneal sensitivity at 1 month and 3 months postoperatively compared with preoperative values, but there were no significant differences in corneal sensitivity between the groups at any postoperative visit.

Slit-lamp examinations revealed the type and severity of staining were significantly less apparent in the plasma treatment group at 1 month and 3 months postoperatively (P < .05).

The plasma drops were effective in promoting epithelial healing from damage due to neurodeprivation of the ocular surface and dryness associated with LASIK.

The study authors said the plasma drops did not have a positive effect on corneal sensitivity recovery because of “limited bioavailability of growth factors in corneal stroma when the substance is topically administered.”