Microperimetry, OCT used together to correlate retinal structure and function
SEATTLE — A weak relationship correlating local retinal sensitivity with local retinal thickness was found using a combination optical coherence tomography and microperimetry instrument, according to a poster here.
“For treatment to be approved, there needs to be a functional benefit,” SriniVas R. Sadda, MD, told Ocular Surgery News at the Association for Research in Vision and Ophthalmology meeting, adding that the study was an effort to build on correlations between structure and function.
Using Spectral OCT/SLO (Optos), the prospective cross-sectional study looked at 24 eyes of 24 subjects with various types of retinal pathology. Point retinal sensitivity and retinal thickness were obtained in a total of 1,080 loci, according to the poster.
There was no significant correlation between the total retinal sensitivity for the entire macula and the mean retinal thickness or total macular volume, the study authors said. Mean total retinal sensitivity was 13.7 ± 2.74 dB, and mean total retinal thickness was 273.55 ± 32.31 µm.
“These findings suggest that retinal functional testing with microperimetry encodes additional information which cannot be captured by gross anatomic measures,” the study authors said. “Correlation of sensitivity with morphometrics of individual retinal sublayers could potentially strengthen these associations and be a topic of future study.”
Disclosure: Sadda is a consult for or receives financial support from Allergan, Carl Zeiss Meditec, Optos and Optovue.