Adjuvant therapy may not affect survival rate of children with retinoblastoma
The survival rate for children with isolated choroidal invasion of retinoblastoma was high without adjuvant therapy, according to a study.
The retrospective analysis analyzed clinical records for 167 children with varying degrees of choroidal invasion who were treated at a single center in Argentina. Adjuvant therapy was not administered to 136 of the children.
“Survival is not jeopardized by the decision to not give adjuvant chemotherapy to children with isolated choroidal invasion provided that two important conditions are available: reliable eye pathologic data and availability of effective second-line therapy,” the study authors wrote. “However, the situation in other developing countries with limited access to intensive therapy for relapse may shift this balance toward the use of adjuvant therapy.”
The 5-year event-free survival probability for the study population was 98.1%; the 5-year overall survival probability was 98.7%.
Children with focal choroidal invasion had a significantly higher 5-year event-free survival probability than children with massive invasion (P = .04), but there was no significant difference between the two groups in terms of 5-year overall survival probability.
The median age at diagnosis was 17 months, and median follow-up was 44 months.