Disclosures: Tommerdahl reports no relevant financial disclosures.
May 09, 2022
2 min read

Greater coffee consumption correlates with lower risk for AKI, compared with no coffee

Disclosures: Tommerdahl reports no relevant financial disclosures.
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Compared with individuals who never drink coffee, those who consume a large amount of coffee are at a lower risk for incident AKI, according to data published in Kidney International Reports.

“Habitual coffee consumption is associated with the prevention of chronic and degenerative diseases including type 2 diabetes, cardiovascular disease and liver disease,” Kalie L. Tommerdahl, MD, of the department of pediatrics at the Children’s Hospital Colorado and University of Colorado Anschutz Medical Campus in Colorado, and colleagues wrote. “We aimed to assess associations between coffee consumption and incident AKI in a large, diverse population of middle-aged adults and hypothesized that habitual coffee consumption would be associated with a lower risk of incident AKI due to the cardiorenal protective properties of both coffee and caffeine.”

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In the Atherosclerosis Risk in Communities (ARIC) study, researchers evaluated 14,207 adults between the ages of 45 and 64 years in the United States. Researchers recruited all participants between 1987 and 1989.

Participants attended seven follow-up visits. At the first visit, researchers asked participants to complete a semiquantitative food frequency questionnaire involving 66 questions to measure coffee consumption.

During the following year, participants reported average coffee consumption of an 8-ounce cup of coffee with the following choices: most never; one to two cups per month; one cup per week; two to four cups per week; five to six cups per week; one cup per day; two to three cups per day; four to six cups per day; and more than six cups per day.

Researchers used the ICD code to define AKI as a hospitalization during the follow-up period.

Researchers identified 1,694 cases of incident AKI during a median of 24 follow-up years among the cohort. Analyses revealed greater coffee consumption correlated with lower risk for AKI vs. no consumption. When accounting for demographic characteristics, socioeconomic status, lifestyle factors and other dietary factors, there was a 15% lower risk of AKI for participants who consumed coffee compared to those who never did.

“Our data support chronic coffee consumption as an opportunity for cardiorenal protection through diet, particularly for the prevention of AKI hospitalizations or procedures,” Tommerdahl and colleagues wrote. “Larger studies evaluating the effects of coffee consumption on kidney perfusion and oxygenation in individuals with impaired kidney function at high risk for AKI, as well as the effects of coffee on anti-inflammatory and antioxidant outcomes, are necessary to fully explain its potential cardiorenal protective effects.”