St. Jude Children’s Research Hospital

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In the Journals

Dasatinib improves outcomes vs. imatinib for pediatric ALL subset

January 17, 2020
Dasatinib appeared more effective than imatinib mesylate for treatment of children with Philadelphia chromosome-positive acute lymphoblastic…
In the JournalsPerspective

Survivors of childhood acute lymphoblastic leukemia at higher risk for type 2 diabetes

January 9, 2020
Survivors of childhood acute lymphoblastic leukemia, particularly those with obesity and/or who received treatment during adolescence, appeared to be…

ASH presents Scholar Awards to fellows, junior faculty

December 22, 2019
ASH announced the recipients of its 2019 Scholar Awards. The awards — presented to hematologists in the United States and Canada who conduct…
Meeting News

Integrated genome, transcriptome sequencing identifies subtypes of AML, myelodysplastic syndrome

December 10, 2019
ORLANDO — The integration of transcriptomic and genomic sequencing data from a large cohort of adults with acute myeloid leukemia or…

Vincristine shortage underscores vulnerability of ‘fragile market’ for crucial treatments

October 23, 2019
A shortage of the chemotherapy drug vincristine, which is essential to the treatment of most pediatric cancers, has left the oncology community…
In the Journals

Physical fitness linked to neurocognitive outcomes of leukemia survivors

October 22, 2019
Reduced exercise capacity may be linked to neurocognitive deficits among survivors of acute lymphoblastic leukemia, according to results of a…
Clinical Trials Snapshot

T-cell Responses to Concurrent HIV and Herpesvirus Infections

Cell Therapy Next, October/November 2019
An observational, prospective cohort study to discover new information about how HIV and herpes viruses interact with the immune system, with a goal…
Clinical Trials Snapshot

TCR-engineered T Cells in Solid Tumors (ACTengine)

Cell Therapy Next, October/November 2019
Phase 1 study evaluating the safety and tolerability of genetically modified autologous T cells expressing a T-cell receptor recognizing a…
Clinical Trials Snapshot

NY-ESO-1 TCR Engineered T Cell and HSC After Melphalan Conditioning Regimen in Treating Participants with Recurrent or Refractory Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Cell Therapy Next, October/November 2019
Phase 1, open-label study evaluating the safety and efficacy of adoptive transfer of autologous NY-ESO-1 CD8-TCR engineered T cells and NY-ESO-1…
Clinical Trials Snapshot

HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

Cell Therapy Next, October/November 2019
Phase 1 study to determine the safety and feasibility of using HERV-E TCR-transduced autologous T Cells in patients with metastatic clear-cell…
Clinical Trials Snapshot

HA-1 T TCR T Cell Immunotherapy for the Treating of Patients with Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

Cell Therapy Next, October/November 2019
Phase 1 study of adoptive immunotherapy with CD8+ and CD4+ memory T cells transduced to express an HA-1-specific T cell receptor for children and…
Clinical Trials Snapshot

Adoptive T Cell Immunotherapy for Advanced Melanoma Using Engineered Lymphocytes

Cell Therapy Next, October/November 2019
Phase 1 dose-escalation clinical trial to determine the phase 2 dose of autologous TIL 1383I TCR gene-modified T cells using a retrovirus for…

The Leukemia & Lymphoma Society awards $13.8 million for research into pediatric blood cancers

October 9, 2019
The Leukemia & Lymphoma Society awarded $13.8 million in new pediatric research grants designed to identify more effective and precise treatments…

ASH presents bridge grants to 19 investigators

October 7, 2019
ASH awarded $150,000 each to 19 investigators through the society’s bridge grant program, designed to sustain promising hematologic research…
In the Journals

11.5 million years of healthy life lost to childhood cancer in 2017

July 30, 2019
Childhood cancer accounted for 11.5 million years of healthy life lost in 2017, with lower-resource nations facing a significantly larger burden than…
In the Journals

BRCA2 mutation may predispose children to lymphoma

July 25, 2019
Inherited heterozygous BRCA2 mutations appeared to increase risk for non-Hodgkin lymphoma in children and adolescents, according to a research…

St. Jude Children’s Research Hospital physician-scientist receives award

July 12, 2019
Esther Obeng, MD, PhD, received the 2019 Gertrude B. Elion Cancer Research Award from American Association for Cancer Research. The award supports…

Dana-Farber/Boston Children’s named nation’s best hospital for pediatric cancer

June 18, 2019
Dana-Farber/Boston Children’s Cancer and Blood Disorders Center has reclaimed its distinction as the No. 1 children’s hospital for cancer…
Cover Story

Sickle cell disease poised for ‘golden age of treatment’ amid progress toward cure

HemOnc Today, June 10, 2019
As researchers work to expand curable approaches for sickle cell disease, new options for managing its acute and chronic complications appear within…
Meeting News

Conquer Cancer Foundation presents Merit Awards at ASCO

June 6, 2019
CHICAGO — The Conquer Cancer Foundation of ASCO presented ASCO Annual Meeting Merit Awards to more than 100 oncology professionals. The awards…