Roswell Park

Roswell Park Comprehensive Cancer Center

This is your central portal for breaking news, the latest research and important updates from Roswell Park Comprehensive Cancer Center. Bookmark this page and check back often for updates.

In the Journals

Antioxidant supplements linked to increased risk for breast cancer recurrence, death

January 16, 2020
Use of antioxidant supplements during chemotherapy, as well as iron and vitamin B12, by patients with breast cancer may increase their risk for…
Feature

DNA-mapping tool shows potential for identifying cancer progression

January 9, 2020
Cover Story

Cancer drug doses: More is not always better

HemOnc Today, December 25, 2019
Historically, the goal of cancer treatment has been to destroy as many cancer cells as possible through chemotherapy or radiation. Guided by this…
In the JournalsPerspective

Propensity score analysis supports blinatumomab vs. standard of care for relapsed/refractory ALL subset

November 20, 2019
Blinatumomab appeared to confer better outcomes than standard of care among adults with relapsed or refractory Philadelphia chromosome-positive acute…

Roswell Park professor promoted to chief of breast pathology

October 15, 2019
Thaer Khoury, MD , FCAP , has been promoted to chief of breast pathology within the department of pathology and laboratory medicine at…
Clinical Trials Snapshot

T-cell Responses to Concurrent HIV and Herpesvirus Infections

Cell Therapy Next, October/November 2019
An observational, prospective cohort study to discover new information about how HIV and herpes viruses interact with the immune system, with a goal…
Clinical Trials Snapshot

TCR-engineered T Cells in Solid Tumors (ACTengine)

Cell Therapy Next, October/November 2019
Phase 1 study evaluating the safety and tolerability of genetically modified autologous T cells expressing a T-cell receptor recognizing a…
Clinical Trials Snapshot

NY-ESO-1 TCR Engineered T Cell and HSC After Melphalan Conditioning Regimen in Treating Participants with Recurrent or Refractory Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Cell Therapy Next, October/November 2019
Phase 1, open-label study evaluating the safety and efficacy of adoptive transfer of autologous NY-ESO-1 CD8-TCR engineered T cells and NY-ESO-1…
Clinical Trials Snapshot

HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

Cell Therapy Next, October/November 2019
Phase 1 study to determine the safety and feasibility of using HERV-E TCR-transduced autologous T Cells in patients with metastatic clear-cell…
Clinical Trials Snapshot

HA-1 T TCR T Cell Immunotherapy for the Treating of Patients with Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

Cell Therapy Next, October/November 2019
Phase 1 study of adoptive immunotherapy with CD8+ and CD4+ memory T cells transduced to express an HA-1-specific T cell receptor for children and…
Clinical Trials Snapshot

Adoptive T Cell Immunotherapy for Advanced Melanoma Using Engineered Lymphocytes

Cell Therapy Next, October/November 2019
Phase 1 dose-escalation clinical trial to determine the phase 2 dose of autologous TIL 1383I TCR gene-modified T cells using a retrovirus for…
In the Journals

Use of algorithm safely reduces therapy for certain children with neuroblastoma

August 19, 2019
A biology- and response-based treatment algorithm helped reduce therapy for subsets of children with intermediate-risk neuroblastoma while…

Ovarian Cancer Research Alliance honors Roswell Park deputy director

July 30, 2019
Ovarian Cancer Research Alliance presented its Rosalind Franklin Prize for Excellence in Ovarian Cancer Research to Kunle Odunsi, MD, PhD, FRCOG
In the Journals

‘Important opportunity’ identified for tamoxifen in triple-negative breast cancer

July 29, 2019
TP53 status may explain the opposite functions of ER-beta in breast cancer cells, with the ER-beta and mutant TP53 combination predicting survival…
Meeting NewsPerspective

MIW815 plus spartalizumab safe, active among certain patients with advanced breast cancer, melanoma

June 17, 2019
CHICAGO — Patients with anti-PD-1-naive triple-negative breast cancer and PD-1-relapsed or refractory melanoma demonstrated antitumor benefit…
In the Journals

Patients with rectal cancer responsive to neoadjuvant therapy may forgo surgery

May 8, 2019
Nonoperative “watch-and-wait” management may be a viable strategy for certain patients with rectal cancer who demonstrate a complete…
Feature

Minimal residual disease status prognostic for PFS in myeloma

May 8, 2019
Minimal residual disease status appeared prognostic for PFS at three specific time points for patients with multiple myeloma, according to results of…
Meeting NewsPerspective

Oral contraceptive birth control reduces risk for aggressive ovarian cancer

April 1, 2019
ATLANTA — Oral contraceptive use appeared associated with a reduced risk for highly fatal aggressive ovarian cancer, with a greater risk…
Point/Counter

Should pediatric cancer survivors previously exposed to neck irradiation undergo ultrasound screening for thyroid cancer?

HemOnc Today, March 10, 2019
POINT We have very limited data on whether active surveillance of patients treated with radiation therapy for a nonthyroid head and neck cancer is…
Cover Story

‘There needs to be urgency’ to address late endocrinopathies in childhood cancer survivors

HemOnc Today, March 10, 2019
For pediatric cancer survivors, the disease and its treatments place them at risk for subsequent health complications, many of which are endocrine…