Perelman School of Medicine, University of Pennsylvania

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Oncologists must be ‘very cautious’ as liquid biopsy use expands

HemOnc Today, January 25, 2020
So-called “liquid biopsies” — noninvasive tests used to evaluate blood for cancer cells or DNA — have been refined…
In the Journals

Proton chemoradiotherapy associated with reduced acute adverse events in locally advanced cancer

January 7, 2020
Proton chemoradiotherapy appeared associated with a substantial reduction in acute adverse events that caused unplanned hospitalizations compared…

An emerging industry looks to take T cells to the cryobank

December 30, 2019
An increasing body of evidence shows that using younger, less heavily pretreated T cells results in more effective chimeric antigen receptor T-cell…
Meeting NewsPerspective

Mosunetuzumab induces remissions in advanced non-Hodgkin lymphoma after CAR-T fails

December 23, 2019
ORLANDO — About 20% of a cohort of patients with aggressive relapsed or refractory non-Hodgkin lymphoma experienced complete response to…

Is it feasible to change the immunotherapy dose schedule for a patient in complete response?

HemOnc Today, December 25, 2019
POINT Immunotherapy represents a novel form of therapy in many ways, and it may not need to be given continuously. Currently approved checkpoint…
Meeting NewsPerspective

Co-mutations may impact response to quizartinib for relapsed/refractory acute myeloid leukemia

December 23, 2019
ORLANDO — Quizartinib significantly prolonged survival compared with salvage chemotherapy among patients with relapsed or refractory acute…
Meeting NewsPerspective

Oral paclitaxel regimen improves outcomes vs. IV formulation in metastatic breast cancer

December 20, 2019
SAN ANTONIO — A novel combination of oral paclitaxel plus encequidar significantly improved overall response rates compared with IV paclitaxel…
Meeting NewsPerspective

Patients with CLL face ‘substantial burden’ of adverse events in real-world treatment setting

December 11, 2019
ORLANDO — Adverse events from treatment for chronic lymphocytic leukemia appeared common among Medicare patients treated in a real-world…
Meeting NewsPerspective

Genetic alterations at diagnosis predict transplant outcomes for older patients with AML

December 7, 2019
ORLANDO — Genetic alterations at diagnosis predicted OS and leukemia-free survival for older individuals with acute myeloid leukemia who…
Meeting News

CRISPR-edited T cells appear safe for patients with cancer

December 7, 2019
ORLANDO — Immune cells genetically edited with CRISPR/Cas9 technology and infused back into patients with multiple myeloma and sarcoma appeared…

Partnership funds research to assess connection between cancer, aging

December 2, 2019
The Partnership for Aging and Cancer Research Program awarded seven grants intended to fund research into the link between aging and cancer. The…

Blood-based assays ‘where we are headed’ to guide therapy decisions

November 21, 2019
Tumor mutational burden seems to have arrived at an uncertain juncture in its exploration as a potential biomarker for response to immunotherapy. …
In the Journals

Experts publish ‘comprehensive’ pediatric psoriasis guidelines

November 18, 2019
The new guidelines from the American Academy of Dermatology and the National Psoriasis Foundation are the first of its kind to focus on pediatric…

Penn program addresses ‘barriers and bias’ unique to women in oncology

November 11, 2019
PHILADELPHIA — More than 40% of U.S. medical students and physicians-in-training over the past 2 decades have been female. However, women…
In the Journals

Plasma cell-free DNA may predict glioblastoma progression

November 4, 2019
Plasma cell-free DNA appeared to be an effective biomarker for tumor burden and a viable prognostic tool for disease progression among…

ASH elects three to leadership positions

October 31, 2019
ASH announced the election of three clinicians to leadership positions within the society. Jane Winter, MD, will serve a 1-year term as vice…
In the Journals

Gilteritinib new standard of care for relapsed, refractory FLT3-mutated acute myeloid leukemia

October 30, 2019
Gilteritinib significantly extended OS and demonstrated higher rates of complete response compared with standard salvage chemotherapy among patients…

Hematologists, oncologists elected to National Academy of Medicine

October 30, 2019
The National Academy of Medicine announced the election of 90 regular members and 10 international members. Election to the academy —…

Studies show oncologists can adapt quickly to new evidence

October 28, 2019
Oncologists acted promptly in response to an FDA restriction last year on the label indication for two immunotherapies, effectively reducing their…
In the Journals

Algorithm predicts short-term mortality among patients with cancer, may foster timely discussions of goals

October 25, 2019
Machine learning algorithms identified patients with cancer who were at risk for short-term mortality and could benefit from immediate discussions…