Children’s Hospital of Philadelphia

This is your central portal for breaking news, the latest research and important updates from Children’s Hospital of Philadelphia. Bookmark this page and check back often for updates.

Meeting News

Chemotherapy may limit ability to develop effective CAR T cells

March 16, 2018
Pediatric patients with solid tumors may have poor-quality T cells compared with patients with leukemia, and certain prior chemotherapies…
In the Journals Plus

Single-dose tisagenlecleucel offers long-term responses for acute lymphoblastic leukemia

February 1, 2018
A single treatment of the chimeric antigen receptor T-cell therapy tisagenlecleucel led to long-term durable remission among pediatric and young…
Meeting News

Engineered stem cells may provide ‘universal’ donor cells for sickle cell disease

January 11, 2018
ATLANTA — A panel of customized induced pluripotent stem cells may allow for more efficient and safe matching of blood for transfusions among…
Meeting News

Dasatinib, chemotherapy combination appears effective in pediatric patients with leukemia subtype

January 5, 2018
ATLANTA — The addition of dasatinib to imatinib plus chemotherapy conferred survival benefit and appeared safe in pediatric patients with…

Celiac symposium highlights importance of research, community partnerships

December 11, 2017
On November 9, the patient advocacy group Beyond Celiac held its first Bold Beyond Research Symposium, where researchers, clinicians and community…
In the Journals Plus

Gene transfer therapy leads to stable factor IX levels in hemophilia B

December 6, 2017
A one-time IV infusion of gene therapy with SPK-9001 appeared associated with sustained level of factor IX coagulant activity of approximately 30%…
In the Journals

Gut microbiota amino acids linked to disease severity in Crohn’s

November 15, 2017
Fecal samples from patients with Crohn’s disease showed as association between severity of the disease, gut dysbiosis and free amino acids…
Meeting News

Omalizumab improves asthma outcomes despite inconsistent adherence

October 30, 2017
BOSTON — Even if children are not fully adherent to treatment, those receiving omalizumab for the management of asthma have a significantly…
In the Journals PlusPerspective

Crizotinib effectively targets ALK pathway in pediatric cancers

October 9, 2017
Crizotinib induced robust and sustained clinical responses in children with relapsed anaplastic large cell lymphoma and metastatic or unresectable…
In the Journals

Families of children treated with ECMO report certain favorable outcomes

October 9, 2017
Family-reported outcomes of pediatric cardiac patients once supported by extracorporeal membrane oxygenation, or ECMO, were encouraging, according to…
Cover StoryPerspective

CAR T-cell therapy approval huge step for oncology, but only ‘beginning of story’

HemOnc Today, September 25, 2017
The FDA’s approval of tisagenlecleucel for the treatment of children and young adults with relapsed or refractory B-cell acute lymphoblastic…
Round Tables

Surgical hip dislocation in children is safe for muscles, preserves blood supply

Orthopedics Today, September 2017
This Orthopedics Today Round Table features surgical hip dislocation in children, a procedure described by Reinhold Ganz, MD, about 17 years ago…
Cover Story

Advancing Standards of Care in Pediatric Rheumatology

Healio Rheumatology, August 2017
The most important challenge facing pediatric rheumatology is a lack of pediatric rheumatologists, according to many experts in the field. The…

Kids First Data Resource Center set to ‘unlock potential’ of genomic data in pediatric cancer

August 16, 2017
The NIH established the Kids First Data Resource Center, a pediatric cancer and rare disease data program that will enable clinicians and researchers…
Spot the Rash

A 13-year-old boy with a worsening neck, arm rash

Infectious Diseases in Children, August 2017
Marissa J. Perman, MD; Scarlett Boulos, MD
A 13-year-old boy presented with a 10-day history of a rash that started on his left arm after receiving his influenza vaccine. Following…

NCI, Children’s Oncology Group collaborate on trial to evaluate targeted drugs for pediatric cancers

July 24, 2017
NCI and the Children’s Oncology Group today announced enrollment opened for a phase 2 study designed to evaluate targeted therapies in children…

Boston Children’s, CHOP ranked best hospitals for pediatric GI, GI surgery

June 27, 2017
Boston Children’s Hospital, Children’s Hospital of Philadelphia and Cincinnati Children’s Hospital Medical Center ranked as the top…

Boston Children’s Hospital named best pediatric hospital by U.S. News & World Report

June 27, 2017
Boston Children’s Hospital has been ranked the No. 1 pediatric hospital in the nation for the fourth consecutive year, according to the…
Meeting NewsVideo

VIDEO: Pembrolizumab may improve response to CAR T-cell therapy in children with ALL

June 20, 2017
CHICAGO — The combination of pembrolizumab and CAR T-cell therapy appeared safe and effective in a subset of patients with acute lymphoblastic…
Spot the Rash

A 12-year-old girl with scattered erythematous papules, pustules on her neck

Infectious Diseases in Children, June 2017
Marissa J Perman, MD; Scarlett Boulos, MD
A 12-year-old girl presented with a 3-week history of an itchy rash on the back of her neck. She was previously treated twice with permethrin 1%…