Perspective from Peter J. Hotez, MD, PhD
November 29, 2018
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Measles cases surge 31%, driven by gaps in vaccination coverage

Perspective from Peter J. Hotez, MD, PhD
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Measles cases surged by 31% worldwide in 2017 — a troubling increase driven by gaps in vaccination coverage that have caused outbreaks of the highly contagious disease in every region of the globe, according to a new report.

The report, published today in MMWR, highlights gains made against measles since the turn of the century — including large decreases in annual incidence and deaths — but paints a grim picture of stagnant vaccination rates and increasing cases since 2010.

According to the report, measles caused nearly 110,000 deaths in 2017. New cases of the disease increased in five of six WHO regions since 2016 and rose more than 6,000% in the Americas alone amid an ongoing epidemic in Venezuela, where endemic transmission of the disease has been re-established.

A large outbreak of measles in Europe means that endemic transmission of the disease has also likely been re-established in some European countries, the authors said.

Child with measles 
Gaps in vaccination coverage have caused recent measles outbreaks in every region of the globe.
Source: CDC/Molly Kurnit

“The resurgence of measles is of serious concern, with extended outbreaks occurring across regions, and particularly in countries that had achieved, or were close to achieving measles elimination,” Soumya Swaminathan, MD, deputy director-general for programs at WHO said in a statement.

“Without urgent efforts to increase vaccination coverage and identify populations with unacceptable levels of under-, or unimmunized children, we risk losing decades of progress in protecting children and communities against this devastating but entirely preventable disease.”

Global estimates of measles vaccination coverage come from data submitted to WHO and UNICEF by 194 countries and underline stalled progress against the disease.

According to the report, although global coverage with one dose of measles-containing vaccine rose from 72% to 85% between 2000 and 2017, virtually all that progress came in the first decade. The rate has remained between 84% and 85% since 2010, and most regions — including the Americas, where coverage hovers around 92% — have seen relatively constant rates, according to the report.

In fact, only the Western Pacific region, which includes China, Japan, Australia, New Zealand and other countries, has seen sustained coverage of more than 95% — the rate needed to prevent outbreaks — since 2006.

There have been gains. Globally, coverage with two doses of measles-containing vaccine rose from 15% in 2000 to 67% in 2017 as the number of countries offering two doses increased, according to the report. From 2000 to 2017, the number of measles cases reported globally declined 80% from 853,479 to 173,330 and annual measles incidence plummeted 83% from 145 cases to 25 per million people. Annual deaths from measles fell 80% from 545,174 to 109,638, with measles vaccination preventing an estimated 21.1 million deaths, a large majority of them in Africa.

But there were increases in 2017 both in the number of cases (132,328) and incidence (19 cases per million people), partly because more countries reported data, the authors said. There also was a drop-off between 2016 and 2017 in the percentage of countries reporting fewer than five new cases per million people, from 69% to 65%.

In addition to a 6,358% increase in reported measles cases in the Americas from 2016 to 2017, there were increases in Africa (100%), the Eastern Mediterranean (481%), Europe (458%), Southeast Asia (3%) and an 82% decrease in the Western Pacific, according to the report. – by Gerard Gallagher

Reference:

Dabbagh A, et al. MMWR Morb Mortal Wkly Rep. 2018;doi:10.15585/mmwr.mm6747a6.