Daily PrEP lowers hip, spine BMD in HIV-seronegative patients
Researchers found a small but statistically significant decrease in bone mineral density in the hip and spine for HIV-seronegative patients taking Truvada daily for pre-exposure prophylaxis, according to recent data.
Further, changes in bone mineral density (BMD) at 24 weeks for patients taking Truvada (emtricitabine/tenofovir disoproxil fumarate, Gilead Sciences; FTC/TDF) was inversely correlated with intracellular tenofovir diphosphate (TFV-DP), which researchers identified in 53% of study patients.
“We report for the first time a quantitative relationship between bone loss and intracellular TFV-DP after 24 weeks of treatment,” Kathleen Mulligan, PhD, professor at the University of California, San Francisco’s division of endocrinology and metabolism, and colleagues wrote. “Bone loss in the spine tended to reverse, albeit not completely, after discontinuation of treatment. These results demonstrate an effect of FTC/TDF that is independent of HIV infection or other ART.”
Mulligan and colleagues performed dual-energy X-ray absorptiometry in 498 patients who were currently enrolled in the Pre-exposure Prophylaxis Initiative Study. The examination was implemented at baseline and 24-week intervals, with plasma and intracellular concentrations of tenofovir measured in those randomly assigned FTC/TDF.
The researchers reported a net difference of 0.91% (95% CI, 1.44% to 0.38%) and 0.61% (95% CI, 0.96% to 0.27%) in spine and hip BMD, respectively, over 24 weeks. There were no statistically significant changes in BMD for the hip and spine after week 24.
TFV-DP levels in the spine averaged 1.42% and averaged 0.85% (± 19%) in the hip compared with the placebo group. Mulligan and colleagues noted that the number of fractures in each group did not differ significantly, and all fractures were related to trauma.
“The results ... provide no reason to modify the CDC’s recommendation that routine DXA monitoring during FTC/TDF for PrEP is not warranted unless there are additional risk factors for fracture,” the investigators said. “Nonetheless ... those beginning PrEP should be counseled on factors important for bone health.” – by Jeff Craven
Disclosure: Mulligan reports no relevant financial disclosures. Please see the full study for a list of all other authors’ relevant financial disclosures.