HBV may increase risk for non-Hodgkin lymphoma
ORLANDO, Fla. — Infection with hepatitis B virus may be a risk factor for non-Hodgkin lymphoma, according to data presented here at Digestive Disease Week 2013.
Researchers from the Marshfield Clinic in Wisconsin conducted a meta-analysis that included 19 case-control studies performed throughout the world. The analysis included a total of 13,947 cases and 1,559,448 controls. In nine of the studies, the controls were non-lymphoma cancer/hospital patients; eight studies incorporated healthy controls, and two studies included both types of controls. In most of the studies (17), patients were diagnosed with hepatitis B by detection of HBsAg, while hepatitis B was self-reported in the remaining two studies. All incidences of non-Hodgkin lymphoma (NHL) were diagnosed with histopathology.
Among the patients with NHL, 1,205 had hepatitis B infection and among the controls, there were 40,592 cases of infection. The risk of hepatitis B was higher for patients with NHL compared with controls (OR=2.53; 95% CI, 2.10-3.03). Significant heterogeneity was not observed across the evaluated studies.
The increased risk of hepatitis B infection was present in both developing and developed countries in subgroup analysis. There was also no difference in risk among controls based in the hospital- and population-based controls.
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Kanth R. #Sa1020. Presented at: Digestive Disease Week; May 18-21, 2013; Orlando.
Disclosure: The researchers report no relevant financial disclosures.