Cervical cancer risk in women with HIV similar to those uninfected
WASHINGTON — Women with and without HIV who had a normal cervical cytology and tested negative for HPV at baseline were at similar risk for both cervical precancer and cancer after 5 years of follow-up, according to data presented during a press briefing at the 2012 International AIDS Conference.
For the study, researchers set out to assess the 3-year and 5-year risk for cervical precancer and cancer in 420 women with HIV compared with 279 women without HIV. Women who received a negative test result at study enrollment were then included in the Women’s Interagency HIV Study between October 2001 and September 2002. Follow-up was through April 2011.
Results indicated that among those with normal cervical cytology at baseline, 88% of those with HIV and 91% of women without HIV, no oncogenic HPV was detected.
During the 5 years of follow-up, there was an overall cumulative incidence of 0.3% and 0.4% of high-grade squamous intraepithelial lesions among HIV-infected women and HIV-uninfected women, respectively.
The cumulative incidence was 2% for cervical intraepithelial neoplasia (CIN) grade 2 during the follow-up period among HIV-infected women with CD4 cell counts of less than 350 cells/mcL and in those with CD4 cell counts between 350 cells/mcL and 499 cells/mcL. The cumulative incidence was 5% in HIV-uninfected women and 6% in women with a CD4 cell count of at least 500 cells/mcL. Overall cumulative incidence among women with HIV was 5%.
Strickler HD. JAMA. 2012;308:362-369.
The researchers report no relevant financial disclosures.