In the Journals

Point-of-care CD4 testing cost-effective in resource-limited countries

Hyle E. PLOS Medicine. 2014;doi:10.1371/journal.pmed.1001725.
Point-of-care CD4 testing at the time of HIV diagnosis may be cost-effective in resource-limited countries, according to new data published in PLOS
In the Journals

CMV increased Alzheimer’s risk, led to rapid cognitive decline

Barnes LL. J Infect Dis. 2014;doi:10.1093/infdis/jiu437.
In a racially diverse population of older adults, cytomegalovirus infection was associated with a higher risk for Alzheimer’s disease and a…
In the Journals

US rates of Cronobacter infection highest in very old, very young

Patrick ME. Emerg Infect Dis. 2014;doi:10.3201/eid2009.140545.
In the United States, the overall rate of Cronobacter species infections appears to be higher than expected, with particular susceptibility observed…
In the Journals

RET mutation identified as potential novel target in SCLC

Dabir S. J Thorac Oncol. 2014;9:1316-1323.
The newly identified RET M918T somatic mutation in small cell lung cancer exhibited widely variable expression and was associated with increased…
In the Journals

HCV antibody decline associated with RNA clearance in MSM with HIV

Vanhommerig J. Clin Infect Dis. 2014;doi:10.1093/cid/ciu695.
Among HIV-positive men who have sex with men, a decline in hepatitis C virus antibodies after acute HCV infection was associated with HCV-RNA…
In the Journals

Anti-CD19 CAR T cells show promise in chemotherapy-refractory DLBCL

Kochenderfer JN. J Clin Oncol. 2014;doi:10.1200/JCO.2014.56.2025.
An infusion of anti-CD19 chimeric antigen receptor T cells induced remission in the majority of patients with chemotherapy-refractory diffuse large…
In the JournalsPerspective

Lung cancer screening of Medicare-eligible patients associated with greater benefits, risks

September 24, 2014
Screen-detected lung cancer prevalence, as well false-positive results, were higher among Medicare-eligible participants compared with younger…
In the JournalsPerspective

Ramucirumab offered no benefit in metastatic HER-2–negative breast cancer

Mackey JR. J Clin Oncol. 2014;doi:10.1200/JCO.2014.57.1513.
The addition of ramucirumab to first-line docetaxel chemotherapy did not significantly improve survival in women with HER-2–negative advanced…
In the Journals

Lung cancer diagnostic test loses specificity in areas with endemic lung infections

Deppen SA. JAMA. 2014;312:1227-1236.
PET imaging with fludeoxyglucose F 18 less reliably diagnosed malignant lung lesions in populations with endemic infectious lung disease, according…
In the Journals

TH-302 demonstrates encouraging activity in soft tissue sarcoma

Chawla SP. J Clin Oncol. 2014;doi:10.1200/JCO.2013.54.3660.
The investigational hypoxia-targeted drug TH-302 was associated with PFS, OS and tumor response rates that compared favorably with other first-line…
In the Journals

Handling, sale of diseased cow carcasses led to 2010 anthrax outbreak in Bhutan

Thapa NK. Emerg Infect Dis. 2014;20:1524-1526.
A 2010 outbreak of Bacillus anthracis among humans was traced to grazing farm animals in the Himalayan nation of Bhutan in South Asia, according…
In the JournalsPerspective

High-dose melphalan plus ASCT significantly extended survival in newly diagnosed myeloma

September 23, 2014
Consolidation with high-dose melphalan plus autologous stem-cell transplantation significantly prolonged PFS and OS with in patients with newly…
In the Journals

USPSTF: Screen sexually active young women for chlamydia, gonorrhea

September 22, 2014
The US Preventive Services Task Force has recommended screening for chlamydia and gonorrhea in sexually active, asymptomatic females aged 24 years…
In the Journals

MSM with, without HIV similarly affected during 2009 H1N1 pandemic

Garg S. Open Forum Infect Dis. 2014;doi:10.1093/ofid/ofu082.
During the 2009 influenza A(H1N1) pandemic in Bangkok, Thailand, rates of seroconversion to the virus were similar among men who have sex with men…
In the Journals

Acute HIV infection may help control chronic HBV

Jiao Y. Clin Infect Dis. 2014;doi:10.1093/cid/ciu710.
According to researchers from Beijing You’an Hospital, Capital Medical University in China, the effects of acute HIV infection improve the…
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