In the JournalsPerspective

Somatic mutations linked to malignant transformation of aplastic anemia

Kulasekararaj AG. Blood. 2014;doi:10.1182/blood-2014-05-574889.
Somatic mutations in patients with aplastic anemia were associated with longer disease duration and an increased risk for transformation to…
In the Journals

Intervention may not reduce risky behaviors among those with HIV

Samet JH. Addiction. 2014;doi:10.1111/add.12716.
Behavioral intervention did not lead to a significant reduction of risky behaviors in HIV-infected heavy drinkers, according to recently published…
In the JournalsPerspective

Addition of bevacizumab to erlotinib improved outcomes in EGFR-mutant NSCLC

Seto T. Lancet Oncol. 2014;doi:10.1016/S1470-2045(14)70381-X.
Patients with EGFR-mutant non–small cell lung cancer who underwent treatment with bevacizumab plus erlotinib demonstrated longer PFS than those…
In the Journals

In California, rate of diagnosed congenital toxoplasmosis low

Jones JL. Emerg Infect Dis. 2014;9:1573-1574.
From 1998 to 2012, only two cases of clinically identified congenital toxoplasmosis were seen in children born in California, according to recent…
In the JournalsPerspective

Increased prostate, pancreatic cancer risks among BRCA mutation carriers support additional screening

Mersch J. Cancer. 2014;doi:10.1002/cncr.29041.
Individuals with BRCA2 mutations demonstrated significantly higher risks for pancreatic cancer and prostate cancer than noncarriers, according to…
In the Journals

ASCO issues policy statement targeting obesity–cancer link

Ligibel JA. J Clin Oncol. 2014;doi:10.1200/JCO.2014.58.4680.
ASCO has released a position statement outlining the society’s commitment to reducing the effect of obesity on cancer and establishing a multipronged…
In the JournalsPerspective

PIK3CA mutation associated with poorer response in HER-2–positive breast cancer

October 3, 2014
Presence of a PIK3CA mutation reduced the likelihood that patients with HER-2–positive breast cancer would achieve pathologic complete response…
In the Journals

Azole-resistant A. fumigatus yet to emerge in US

Pham C. Emerg Infect Dis. 2014;20:1498-1503.
Azole-resistant Aspergillus fumigatus is common in Europe; however, the rates are extremely low in the United States, according to CDC…
In the Journals

Genetic changes identified in second wave of H7N9 epidemic in China

Lu J. Emerg Infect Dis. 2014;20:1582-1583.
Influenza A(H7N9) isolates from a second wave of the 2013-2014 epidemic in China were genetically different than those in the first wave, according…
In the Journals

Tdap vaccination rate low among pregnant women on Medicaid

Housey M. MMWR. 2014;63:839-842.
Only 14.3% of women on Medicaid in Michigan received the Tdap vaccine during their pregnancies from November 2011 to February 2013, according to…
In the Journals

Adjuvant FOLFOX extended DFS in locally advanced rectal cancer

Hong YS. Lancet Oncol. 2014;doi:10.1016/S1470-2045(14)70377-8.
The addition of oxiliplatin to fluorouracil and leucovorin extended DFS among patients with locally advanced rectal cancer who underwent preoperative…
In the Journals

After long-term ART, HIV mortality in S. Africa, N. America comparable

Boulle A. PLoS Med. 2014;doi:10.1371/journal.pmed.1001718.
Researchers from the University of Cape Town in South Africa have found that the mortality rate among patients on HIV treatment in South African…
In the Journals

Less disease education linked to greater decisional conflict in prostate cancer

Kaplan AL. Cancer. 2014;doi:10.1002/cncr.28755.
Patients with less knowledge about prostate cancer are more likely to have decisional conflict and have less confidence in their decision-making…
In the Journals

Rapid response, inspector experience critical in E. coli outbreaks in UK

Pennington TH. Infect Drug Resist. 2014;4:211-222.
A review of Escherichia coli O157 outbreaks in the United Kingdom from the 1980s to 2013 highlighted two key lessons: Rapid response to an outbreak…
In the Journals

MERS fatality rates highest among men

Alghamdi I. Int J Gen Med. 2014;7:417-423.
The recent epidemic of Middle East respiratory syndrome coronavirus in Saudi Arabia had high fatality rates, especially among men, according to the…
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