In the Journals

Flu vaccine may be most effective in patients not vaccinated in past 5 years

McLean HQ. Clin Infect Dis. 2014;doi:10.1093/cid/ciu680.
Influenza vaccination appears to confer protection against influenza infection regardless of a patient’s vaccination history, according to…
In the JournalsPerspective

GVHD prophylaxis with single-agent cyclophosphamide effective after allogeneic transplant

Kanakry CG. J Clin Oncol. 2014;doi:10.1200/JCO.2013.54.0625.
Post-transplant graft-versus-host disease prophylaxis with single-agent cyclophosphamide appeared safe and effective in patients who underwent…
In the Journals

Novel mutation detected in nearly 20% of colorectal, endometrial cancers

Giannakis M. Nat Genet. 2014; Published online ahead of print Oct. 26.
Somatic mutations of RNF43 were detected in nearly one of every five colorectal cancers and endometrial cancers, a finding that suggests the novel…
In the Journals

High rate of culture conversion observed with bedaqualine for TB

Guglielmetti L. Clin Infect Dis. 2014;doi:10.1093/cid/ciu786.
Compassionate use of bedaquiline, combined with other drugs, resulted in culture conversion in almost all patients with multidrug-resistant…
In the JournalsPerspective

Maintenance pazopanib extended PFS, not OS in ovarian cancer

du Bois A. J Clin Oncol. 2014;doi:10.1200/JCO.2014.55.7348.
Maintenance therapy with pazopanib extended PFS by about 45% among women with ovarian cancer whose disease did not progress during first-line…
In the Journals

Brief intervention improved sexual function after oophorectomy

Bober SL. J Sex Med. 2014;doi:10.1111/jsm.12713.
Women with the BRCA1 or BRCA2 mutations who underwent risk-reducing salpingo oophorectomy and experienced menopause-related sexual dysfunction and…
In the Journals

Efficacy of VTE chemoprophylaxis in otolaryngology patients varied by subgroup

Bahl V. JAMA Otolaryngol Head Neck Surg. 2014;doi:10.1001/jamaoto.2014.2254.
The efficacy and safety of venous thromboembolism chemoprophylaxis for individuals undergoing otolaryngologic surgery varied based on Caprini risk…
In the JournalsPerspective

Recombinant Factor VIII product increased inhibitor development risk

Calvez T. Blood. 2014;doi:10.1182/blood-2014-07-586347.
One recombinant Factor VIII product was associated with an increased risk for inhibitor formation compared with similar products for the treatment of…
In the Journals

Tumor characteristics influenced impact of adjuvant radiotherapy in prostate cancer

Abdollah F. J Clin Oncol. 2014;doi:10.1200/JCO.2013.54.7893.
Tumor characteristics considerably influenced the impact of adjuvant radiotherapy on survival outcomes in patients with node-positive prostate…
In the Journals

Cutaneous leishmaniasis incidence in Israel increased 10-fold from 2001-2012

Gandacu D. Emerg Infect Dis. 2014;doi:10.3201/eid2010.140182.
After a 15-year period of decreased incidence of cutaneous leishmaniasis in Israel, a recent resurgence of the disease appears to have occurred in…
In the JournalsPerspective

FOLFOXIRI plus bevacizumab improved outcomes, increased toxicity in metastatic colorectal cancer

Loupakis F. N Engl J Med. 2014;doi:10.1056/NEJMoa1403108.
Patients with metastatic colorectal cancer who received first-line treatment with bevacizumab plus FOLFOXIRI chemotherapy demonstrated significantly…
In the Journals

Risk-adjusted model reveals little variation in hospital readmissions after colorectal cancer surgery

Lucas DJ. JAMA Surg. 2014;doi:10.1001/jamasurg.2014.988.
Researchers who used a risk-adjusted model to evaluate readmission rates after colorectal cancer surgery found little variation between hospitals…
In the Journals

Men, African-Americans at highest risk for body lice among homeless in San Francisco

Bonilla DL. Emerg Infect Dis. 2014;20:1645-1651.
The existence of body lice appeared to be positively correlated with male gender, African-American ethnicity and sleeping outdoors among homeless…
In the Journals

Aprepitant regimen reduced CINV in post-transplant myeloma

Schmitt T. J Clin Oncol. 2014;doi:10.1200/JCO.2013.55.0095.
The addition of the NK-1 antagonist aprepitant to granisetron and dexamethasone reduced nausea and vomiting among patients with myeloma who underwent…
In the Journals

Everolimus–exemestane combination failed to significantly extend OS in advanced breast cancer

Piccart M. Ann Oncol. 2014;doi:10.1093/annonc/mdu456.
The addition of everolimus to exemestane extended OS in postmenopausal women with HR-positive, HER-2–negative advanced breast cancer, but the…
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