In the Journals

Recorded outbreaks, unique diseases increased since 1980

Smith KF. J R Soc Interface. 2014;doi:10.1098/rsif.2014.0950.
The number of recorded outbreaks and unique diseases around the world seems to have increased since 1980 whereas per capita cases declined, …
In the JournalsPerspective

Weekly prophylaxis with nonacog beta pegol safe, effective for hemophilia B

Collins PW. Blood. 2014;doi:10.1182/blood-2014-05-573055.
Nonacog beta pegol effectively treated bleeding episodes and was associated with low annualized bleeding rates in patients with hemophilia B…
In the Journals

HCW exposure to rabies required conservative approach for PEP

Kan VL. Clin Infect Dis. 2014;doi:10.1093/cid/ciu850.
Rabies poses a significant concern for health care workers who are treating patients with the infection, and a conservative approach…
In the Journals

Shorter therapy did not compromise outcomes in low-risk embryonal rhabdomyosarcoma

Walterhouse DO. J Clin Oncol. 2014;doi:10.1200/JCO.2014.55.6787.
Shorter-duration therapy with vincristine, dactinomycin and lower-dose cyclophosphamide with radiation therapy did not compromise failure-free…
In the Journals

Novel poxvirus caused cutaneous infections in patients exposed to farm animals

Osadebe LU. Clin Infect Dis. 2014;doi:10.1093/cid/ciu790.
Clinicians should consider the possibility of novel poxviruses when presented with cutaneous infections, particularly in patients with known…
In the Journals

Longer course of first-line therapy provided no survival benefit in NSCLC

Rossi A. Lancet Oncol. 2014;15:1254-1262.
Patients with advanced non–small cell lung cancer treated with six cycles of platinum-based therapy demonstrated no survival advantage compared…
In the Journals

Maternal pertussis vaccine during pregnancy protected infants

Dabrera G. Clin Infect Dis. 2014;doi:10.1093/cid/ciu821.
Data from a case-control study confirmed that a pertussis vaccine given during pregnancy protected infants from infection after birth. “Our…
In the Journals

FOLFIRI may be viable first-line regimen for advanced gastric, esophagogastric junction adenocarcinoma

Guimbaud R. J Clin Oncol. 2014;doi:10.1200/JCO.2013.54.1011.
Patients with advanced gastric and esophagogastric junction adenocarcinoma who underwent first-line treatment with fluorouracil, leucovorin and…
In the Journals

Gemcitabine regimen effective in relapsed, refractory aggressive lymphomas

October 28, 2014
Patients with relapsed or refractory aggressive lymphomas treated with gemcitabine, dexamethasone and cisplatin prior to autologous stem cell…
In the Journals

Immunocompromised patients with HSV meningitis may benefit from antiviral therapy

Noska A. Clin Infect Dis. 2014;doi:10.1093/cid/ciu772.
While immunocompetent patients with herpes simplex virus meningitis can be successfully managed with symptomatic treatment alone…
In the Journals

Patient costs greater at hospital-owned physician groups

Robinson JC. JAMA. 2014;312:1663-1669.
Hospital-owned physician groups, often aggregated in order to provide coordinated care, had higher costs per patient than physician-owned…
In the Journals

Postsurgical surveillance sufficient for stage I nonseminoma germ cell cancer

Daugaard G. J Clin Oncol. 2014;doi:10.1200/JCO.2013.53.5831.
Most men with stage I nonseminoma germ cell cancer who undergo radical orchiectomy can be followed with surveillance, according to results of a…
In the Journals

Anticonvulsant drug may play a role in the development of new antibiotics

Stoke JM. eLife. 2014;doi:http://dx.doi.org/10.7554/eLife.03574
The anticonvulsant drug lamotrigine appears to hinder the assembly of bacterial ribosomes, and may therefore play a role in the development of a…
In the JournalsPerspective

Branched-chain amino acids linked to future pancreatic cancer diagnosis

Mayers JR. Nat Med. 2014;doi:10.1038/nm.3686.
Adults who had elevated plasma levels of branched-chain amino acids were at greater than twice the risk for pancreatic cancer, according to study…
In the Journals

Bisphosphonates may reduce risk for bone metastases in women with breast cancer

Kremer R. J Natl Cancer Inst. 2014;doi:10.1093/jnci/dju264.
Women with breast cancer who used low-dose oral bisphosphonates for postmenopausal osteoporosis demonstrated a reduced risk for bone metastases…
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