In the Journals Plus

Pediatric fracture risk varies by ethnicity

Grgic O, et al. Bone. 2019;doi:10.1016/j.bone.2019.01.019.
Children with European ancestry are twice as likely to sustain a fracture vs. Asian children and 1.5 times more likely to experience a fracture vs…
In the Journals Plus

Probiotics fail to prevent gestational diabetes in high-risk pregnant women

Callaway LK, et al. Diabetes Care. 2019;doi:10.2337/dc18-2248.
Administering probiotics in the second trimester of pregnancy is not an effective strategy for preventing gestational diabetes in women with…
In the Journals Plus

Depressive symptoms in type 1 diabetes linked to extended hyperglycemia, brain lesions

Nunley KA, et al. Diabet Med. 2018;doi:10.1111/dme.13879.
Middle-aged adults with type 1 diabetes are more likely to experience depressive symptoms than those without, and extended hyperglycemia and more…
In the Journals Plus

Risk for infective endocarditis related to injection drug use increasing

Weir MA, et al. Can Med Assoc J. 2019;doi:10.1503/cmaj.180694.
A recent study of people who inject drugs identified a “substantial and progressive” increase in their risk for infective endocarditis…
In the Journals PlusPerspective

OVIVA: Oral therapy noninferior to IV therapy for bone and joint infections

Li HK, et al. N Engl J Med. 2019;doi:10.1056/NEJMoa1710926.
Oral antibiotic therapy is noninferior to IV antibiotic therapy when used in the first 6 weeks of treatment for complex bone and joint infections…
In the Journals Plus

Regorafenib confers 'substantial' survival benefit in recurrent glioblastoma

Lombardi G, et al. Lancet Oncol. 2018;doi:10.1016/S1470-2045(18)30675-2.
Stupp R. Lancet Oncol. 2018;doi:10.1016/S1470-2045(18)30827-1.
Regorafenib conferred an encouraging OS benefit compared with lomustine among patients with recurrent glioblastoma, according to a randomized…
In the Journals Plus

Ipragliflozin yields loss of fat, not muscle in type 2 diabetes

Inoue H, et al. J Diabetes Investig. 2018;doi:10.1111/jdi.12985.
The lower body weight associated with the SGLT2 inhibitor ipragliflozin is the result of fat mass reduction with muscle mass and bone mineral content…
In the Journals PlusPerspective

Detection of JAK2 V617F mutations linked to myeloproliferative neoplasms

Riedlinger G, et al. JAMA Oncol. 2019;doi:10.1001/jamaoncol.2018.6286.
JAK2 V617F mutations detected by solid tumor sequencing appeared associated with coexistent myeloproliferative neoplasms, according to a…
In the Journals Plus

Trunk-to-leg fat ratio may predict cardiometabolic risk in adolescents

Cioffi CE, et al. Pediatr Obes. 2019;doi:10.1111/ijpo.12509.
A high trunk-to-leg fat ratio among adolescents may predict risks for developing several markers for cardiometabolic disease, including insulin…
In the Journals Plus

'Traditional British' diet may increase sarcopenia risk

Granic A, et al. Clin Nutr. 2019;doi:10.1016/j.clnu.2019.01.009.
Eating a diet with higher proportions of red meat, potatoes, gravy and butter may increase the risk for sarcopenia in older British adults compared…
In the Journals Plus

DPP-IV inhibitor shows little effect on adipose tissue inflammation

Koska J, et al. Diabet Med. 2018;doi:10.1111/dme.13889.
The DPP-IV inhibitor saxagliptin has a minimal effect on adipose tissue inflammation, arteriole vasodilation and postprandial endothelial function in…
In the Journals Plus

Investigational Ebola treatment yields positive results in phase 1 trial

Gaudinski MR, et al. Lancet. 2019;doi.org/10.1016/S0140-6736(19)30036-4.
MAb114, an investigational Ebola treatment, is safe, well tolerated, and easy to administer, according to results from an early-stage clinical trial…
In the Journals Plus

Adipose tissue insulin sensitivity may signal metabolic abnormalities in Asian men

Sugimoto D, et al. J Clin Endocrinol Metab. 2019;doi:10.1210/jc.2018-02190.
Among healthy Japanese men without obesity, reduced adipose tissue insulin sensitivity was associated with liver fat accumulation, lower insulin…
In the Journals PlusPerspective

Estradiol level influences fracture risk during menopause transition

Cauley JA, et al. J Clin Endocrinol Metab. 2019;doi:10.1210/jc.2018-02047.
Among menopausal women, a doubling of serum estradiol was associated with a 10% lower risk for fracture, independent of menopausal stage and level of…
In the Journals Plus

Acute kidney injury a growing burden among patients receiving cancer therapy

Kitchlu A, et al. J Natl Cancer Inst. 2018;doi:10.1093/jnci/djy167.
Acute kidney injury appeared to be a common and considerable burden among patients receiving systemic treatment for cancer, according to a…
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