In the Journals Plus

Benefits of low-dose methotrexate in HIV patients unclear

Hsue PY, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciy781.
In a phase 2 trial performed in older HIV-infected adults who have or are at an increased risk for atherosclerotic cardiovascular disease, low-dose…
In the Journals Plus

Treatment algorithm an asset for antibiotic stewardship

Claeys KC, et al. Open Forum Infect Dis. 2018; doi.org/10.1093/ofid/ofy233.
Researchers tested a stewardship-driven antibiotic treatment algorithm, incorporating rapid diagnostic testing into the management of gram-negative…
In the Journals Plus

Insurance rates rise for head, neck cancer among Medicaid expansion states

Cannon RB, et al. JAMA Otolaryngol Head Neck Surg. 2018;doi:10.1001/jamaoto.2018.1792.
Li RJ and McConnell J. JAMA Otolaryngol Head Neck Surg. 2018;doi:10.1001/jamaoto.2018.1953.
Medicaid expansion under the Affordable Care Act increased insurance rates among patients with head and neck squamous cell carcinoma, according a…
In the Journals PlusPerspective

Adrenal vein sampling may expose patients with primary aldosteronism to excess radiation

Fuss CT, et al. Eur J Endocrinol. 2018;doi:10.1530/EJE-18-0328.
Patients with primary aldosteronism undergoing adrenal vein sampling to diagnose disease subtype may be exposed to “fairly high” values…
In the Journals Plus

Vitamin D deficiency increases risk for metabolic syndrome in Chinese youths

Fu J, et al. Clin Nutr. 2018;doi:10.1016/j.clnu.2018.08.039.
Adolescents and young adults with vitamin D deficiency are nearly 2.5 times more likely to have metabolic syndrome vs. those without vitamin D…
In the Journals Plus

Puppies: a source of multidrug-resistant pathogens

Montgomery MP, et al. MMWR. 2018;doi:10.15585/mmwr.mm6737a3.
A recent outbreak showed that puppies can be a source of Campylobacter infections in humans — including multidrug-resistant infections —…
In the Journals Plus

S. aureus originated in humans, jumped back and forth between livestock

Richardson EJ, et al. Nat Ecol Evol. 2018; doi.org/10.1038/s41559-018-0617-0.
Humans were likely the original source of Staphylococcus aureus, which jumped back and forth between people and livestock over thousands of years…
In the Journals Plus

Use of medications associated with rising osteoporosis risk

Skjødt MK, et al. Bone. 2018;doi:10.1016/j.bone.2018.08.019.
The use of medications associated with the development of osteoporosis has steadily increased across Denmark in the past 16 years, particularly by…
In the Journals PlusPerspective

CDC: 14% of US adults have diabetes, many unaware of disease status

Mendola ND, et al. NCHS Data Brief. 2018;319:1-8.
The prevalence of diabetes among adults in the United States rose to 14% between 2013 and 2016, with nearly 31% of those with diabetes unaware they…
In the Journals Plus

High-dose chemotherapy improves survival in Ewing sarcoma

Whelan J, et al. J Clin Oncol. 2018;doi:10.1200/JCO.2018.78.2516.
Gorlick R, et al. J Clin Oncol. 2018;doi:10.1200/JCO.2018.79.3489.
A high-dose combination of busulfan and melphalan with autologous stem cell transplant improved survival compared with standard-of-care vincristine…
In the Journals Plus

Hospitals could reduce HAIs by up to 55%

Schreiber PW, et al. Infect Control Hosp Epidemiol. 2018;doi:10.1017/ice.2018.183.
A large systematic review and meta-analysis showed that hospitals could reduce health care-associated infections, or HAIs, by 35% to 55% with…
In the Journals Plus

Poor insulin sensitivity can slow information processing, reaction time

Niemiro GM, et al. Obesity. 2018;doi;10.1002/oby.22276.
Cognitive performance in adults with obesity and overweight was negatively affected by poor glucose tolerance and increased visceral fat, according…
In the Journals Plus

Brentuximab vedotin plus gemcitabine safe, active for young patients with Hodgkin lymphoma

Cole PD, et al. Lancet Oncol. 2018;doi:10.1016/S1470-2045(18)30426-1.
Vitolo U and Chiappella A. Lancet Oncol. 2018;doi:10.1016/S1470-2045(18)30510-2.
Salvage treatment with the combination of brentuximab vedotin and gemcitabine showed antitumor activity among children and young adults with…
In the Journals Plus

High percentage of exposed HCWs infected in Ebola, Marburg outbreaks

Selvaraj SA, et al. J Infect Dis. 2018;doi.org/10.1093/infdis/jiy435.
Based on findings from more than 20 past and present Ebola and Marburg outbreaks, researchers reported consistently high infection rates among…
In the Journals Plus

Study data reveal ‘complexity’ of evaluating benefit of breast cancer screening

Beau AB, et al. J Clin Oncol. 2018;doi:10.1200/JCO.2018.78.0270.
Inviting women to mammography screenings may reduce breast cancer mortality by up to 20%, according to retrospective study of Danish national…
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