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In the Journals Plus

Several medications safe for comanagement of type 2 diabetes, osteoporosis

Paschou SA, et al. J Clin Endocrinol Metab. 2017;doi:10.1210/jc.2017-00042.
A recent comprehensive review published in The Journal of Clinical Endocrinology & Metabolism identifies metformin, sulfonylureas, DPP-IV…
In the Journals Plus

Maintained weight loss for 1 year increases insulin sensitivity in women

Clamp LD, et al. Nutr Diabetes. 2017;doi:10.1038/nutd.2017.31.
Women with overweight or obesity who maintained at least 15% reduction in body weight for 12 months were more likely to have improved insulin…
In the Journals Plus

Midostaurin extends survival in acute myeloid leukemia with FLT3 mutation

Stone RM, et al. N Engl J Med. 2017;doi:10.1056/NEJMoa1614359.
The addition of midostaurin to standard chemotherapy improved OS and EFS among patients with acute myeloid leukemia and FLT3 mutation, according to…
In the Journals Plus

Mood, quality of life worse in newly diagnosed incurable cancer

Nipp RD, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2016.71.3404.
Awareness of prognosis appeared associated with worse mood and quality of life among patients newly diagnosed with incurable cancer, study data
In the Journals Plus

Childhood fractures not predictive of BMD, bone strength in young men

Chevally T, et al. J Bone Miner Res. 2017;doi:10.1002/jbmr.3174.
The occurrence of fractures in boys did not predict bone fragility of men in early adulthood, study data from Switzerland and the Netherlands
In the Journals Plus

Washington, D.C., facilities demonstrated 5% CRE prevalence

Reuben J, et al. Infect Control Hosp Epidemiol. 2017;doi:10.1017/ice.2017.110.
Roughly 5% of all inpatients in Washington, D.C. health care facilities tested positive for carbapenem-resistant Enterobacteriaceae, according to
In the Journals Plus

Sugary drink consumption associated with type 2 diabetes risk in women

Papier K, et al. Nutr Diabetes. 2017;doi:10.1038/nutd.2017.27.
Thai woman who reported consuming at least one sugar-sweetened beverage per day were twice as likely to develop type 2 diabetes over 8 years vs…
In the Journals PlusPerspective

Transition to denosumab monotherapy after combination results in favorable BMD changes

Tsai JN, et al. J Bone Miner Res. 2017;doi:10.1002/jbmr.3198.
Postmenopausal women with osteoporosis who switched from combination denosumab therapy to denosumab monotherapy experienced the most favorable total…
In the Journals Plus

Concentrated broccoli sprout extract may reduce fasting blood glucose in type 2 diabetes, obesity

Axelsson AS, et al. Sci Transl Med. 2017;doi:10.1126/scitranslmed.aah4477.
A small group of Scandinavian adults with poorly controlled type 2 diabetes and obesity saw a reduction in both HbA1c and fasting plasma glucose with…
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Cost of hospital-based end-of-life care high for elderly with brain tumors

Dover LL, et al. JAMA Oncol. 2017;doi:10.1001/jamaoncol.2017.1624.
Hospital-based end-of-life care for elderly patients with malignant brain tumors is associated with up to $16,000 in expenses, according to a…
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Glycemic variability tied to depressive symptoms in diabetes

Ravona-Springer R, et al. Diabetes Care. 2017;doi:10.2337/dc16-2754.
Older adults with type 2 diabetes have an increased risk for higher depressive symptoms with greater variability in glycemic control whereas mean…
In the Journals PlusPerspective

Delayed TSH elevation associated with invasive procedures in neonatal ICU newborns

Zung A, et al. J Clin Endocrinol Metab. 2017;doi:10.1210/jc.2017-00701.
Newborns with delayed thyroid-stimulating hormone elevation may experience a greater need for surgery and other invasive procedures compared with…
In the Journals Plus

Additional screening improves detection of new breast cancers following surgery

Cho N, et al. JAMA Oncol. 2017;doi:10.1001/jamaoncol.2017.1256.
The addition of MRI or ultrasonography to annual mammography…
In the Journals Plus

Lenvatinib improves OS in older patients with differentiated thyroid cancer

Brose MS, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2016.71.6472.
Lenvatinib demonstrated higher toxicity in older patients with radioiodine-refractory differentiated thyroid cancer, according to data from a phase
In the Journals Plus

Cadmium exposure increases osteoporosis risk in Chinese adults

Lv Y, et al. J Bone Miner Res. 2017;doi:10.1002/jbmr.3151.
Chinese adults living in areas exposed to cadmium pollution for at least 15 years are more likely to develop osteoporosis and show signs of renal…
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Flublok Quadrivalent provides better protection than IIV4

Dunkle LM, et al. N Engl J Med. 2017;doi:10.1056/NEJMoa1608862.
Flublok Quadrivalent was 30% more effective in preventing influenza than an egg-derived inactivated quadrivalent influenza vaccine, according to…
In the Journals Plus

Elevated immunoglobins increase prediabetes risk in Chinese adults

Wang H, et al. Metabolism. 2017;doi:10.1016/j.metabol.2017.05.008.
Chinese adults with elevated levels of immunoglobins E and A are more likely to develop prediabetes compared with adults who have normal…
In the Journals PlusPerspective

First-line nivolumab fails to extend PFS in non–small cell lung cancer

Carbone DP, et al. N Engl J Med. 2017;doi:10.1056/NEJMoa1613493. Garon EB. N Engl J Med. 2017;doi:10.1056/NEJMe1705692.
Nivolumab did not result in longer PFS than platinum-based chemotherapy as first-line treatment for stage IV or recurrent non–small cell lung…
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Azacitidine-based combination may improve response rate in chronic myelomonocytic leukemia

Sekeres MA, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2015.66.2510.
Overall response rate improved with the addition of lenalidomide to azacitidine in patients with chronic myelomonocytic leukemia, according to…
In the Journals Plus

Study indicates potential link between influenza during pregnancy and autism

Mahic M, et al. mSphere. 2017;doi:10.1128/mSphere.00159-17.
Although researchers found no evidence that maternal influenza alone was associated with autism spectrum disorder among children, they did observe a…