In the Journals Plus

Cadazolid inferior to vancomycin for treating C. difficile

Gerding DN, et al. Lancet Infect Dis. 2019;doi:10.1016/ S1473-3099(18)3061.
Phase 3 study findings showed that cadazolid is inferior to vancomycin for treating Clostridioides difficile. Johnson & Johnson had been…
In the Journals PlusPerspective

Patients with sickle cell disease may have lower risk for C. difficile

Ahmed J, et al. N Engl J Med. 2019;doi:10.1056/NEJMc1815711.
Findings from a retrospective cohort study conducted at a single hospital suggest that patients with sickle cell disease have a lower — and not…
In the Journals Plus

Influenza A causes more severe illness, delayed clinical improvement

Wang Y, et al. Open Forum Infect Dis. 2019;doi:10.1093/ofid/ofz053.
In hospitalized patients, influenza A is associated with more severe illness and delayed clinical improvement compared with influenza B, according to…
In the Journals Plus

Karius Test identifies pathogens more quickly than standard tests

Blauwkamp TA, et al. Nat Microbiol. 2019;doi:10.1038/s41564-018-0349-6.
The Karius Test has been validated for detecting pathogens and shown to identify quicker than test, according tostudy published in Nature
In the Journals Plus

Aerosol transmission of CRAB possible from ventilated patients

Mousa M, et al. Infect Control Hosp Epidemiol. 2019;doi:10.1017/ice.2018.335.
Researchers detected carbapenem-resistant Acinetobacter baumannii, or CRAB, in the air adjacent to ventilated patients with CRAB respiratory…
In the Journals Plus

Genetic testing guidelines miss nearly 50% of breast cancers with actionable variants

Beitsch PD, et al. J Clin Oncol. 2018;doi:10.1200/JCO.18.01631.
Milliron KJ and Griggs JJ. J Clin Oncol. 2018;doi:10.1200/JCO.18.01952.
Nearly half of patients whose breast cancer is revealed by expanded genetic testing to have a clinically actionable pathogenic or likely pathogenic…
In the Journals PlusPerspective

Cytoreductive surgery with chemotherapy often safer than other high-risk oncologic procedures

Foster J, et al. JAMA Netw. Open. 2019;doi:10.1001/jamanetworkopen.2018.6847.
Smith M and Nathan H. JAMA Netw. Open. 2019;doi:10.1001/jamanetworkopen.2018.6839.
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy proved to be as safe as or safer than other oncologic procedures with similar…
In the Journals Plus

Two-thirds of hospital-onset bacteremia, fungemia are preventable

Dantes RB, et al. Infect Control Hosp Epidemiol. 2019;doi:10.1017/ice.2018.339.
Two-thirds of all hospital-onset bacteremia and fungemia, or HOB, events and half of nonskin commensal HOB events are potentially preventable…
In the Journals Plus

'Intensification inertia' potentially hinders HbA1c goal attainment

Pantalone KM, et al. Diabet Med. 2019;doi:10.1111/dme.13900.
Intensifying drug therapies did not help most adults with type 2 diabetes attain HbA1c goals, but the best results were seen with the addition of a…
In the Journals Plus

HT does not alter vitamin D levels in transgender adults

Chen H, et al. J Clin Endocrinol Metab. 2019;doi:10.1210/jc.2018-02602.
Transgender women experience only small changes in vitamin D-binding protein after 3 months of estradiol therapy, whereas testosterone therapy was…
In the Journals Plus

Cervical cancer study suggests ‘global elimination is within reach’

Brisson M and Drolet M. Lancet Oncol. 2019;doi:10.1016/S1470-2045(19)30072-5.
Simms KT, et al. Lancet Oncol. 2019;doi:10.1016/S1470-2045(18)30836-2.
A rapid scale-up of HPV vaccination and screening could effectively eliminate
In the Journals Plus

Nodular thyroid disease risk increased for adults with acromegaly

Dogansen SC, et al. Pituitary. 2019;doi:10.1007/s11102-018-0923-1.
Adults with acromegaly may be prone to developing nodular thyroid disease and advanced nodule growth, according to findings published in…
In the Journals Plus

Electronically delivered feedback reduces antibiotic prescribing for RTIs

Gulliford MC, et al. BMJ. 2019;doi:10.1136/bmj.l236.
Electronically delivered prescribing feedback led to “moderate” reductions in unnecessary antibiotic prescribing for respiratory tract…
In the Journals Plus

Data show 'clear evidence' of HPV vaccine impact on cervical precancer

McClung NM, et al. Cancer Epidemiol Biomarkers Prev. 2019;doi:10.1158/1055-9965.EPI-18-0885.
The proportion of cervical precancers positive for HPV types 16 and 18 declined significantly between 2008 and 2014, particularly among vaccinated…
In the Journals PlusPerspective

Direct oral anticoagulants do not increase incidence of intracranial hemorrhage

Carney, BJ, et al. J Thromb Haemost. 2019;doi:10.1111/jth.14336.
Direct oral anticoagulants did not appear associated with a higher incidence of intracranial hemorrhage compared with low-molecular-weight heparin in…
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