ASCO Annual Meeting
ASCO Annual Meeting
Issue: June 25, 2018
Perspective from Alberto Pappo, MD
Perspective from Margaret von Mehren, MD
June 03, 2018
2 min read
Save

Maintenance chemotherapy improves OS in rhabdomyosarcoma

Issue: June 25, 2018
Perspective from Alberto Pappo, MD
Perspective from Margaret von Mehren, MD
You've successfully added to your alerts. You will receive an email when new content is published.

Click Here to Manage Email Alerts

We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com.

CHICAGO — Maintenance chemotherapy after standard intensive therapy improved DFS and OS rates among children with rhabdomyosarcoma, according to study results presented during the plenary session of the ASCO Annual Meeting.

“Maintenance therapy represents a novel well-tolerated effective strategy in patients with high-risk rhabdomyosarcoma,” Gianni Bisogno, MD, PhD, professor in the department of women's and children's health, hematology/oncology division at Padova University Hospital in Padova, Italy, said during a press conference. “This study establishes the new standard of treatment for patients with high-risk rhabdomyosarcoma, at least in the European Union.”

Rhabdomyosarcoma — a rare tumor of mesenchymal origin — is diagnosed in approximately 350 children in the United States and 320 children in the European Union annually.

“It is a very aggressive tumor but, with modern intensive treatment, 70% to 80% of children can be cured,” Bisogno said.

Bisogno and colleagues from European pediatric Soft tissue sarcoma Study Group, or EpSSG, randomly assigned patients aged 6 months to 21 years with high-risk rhabdomyosarcoma to standard intensive therapy (n = 186) or standard intensive therapy followed by maintenance chemotherapy (n = 185).

Standard intensive therapy included nine cycles of high-dose chemotherapy (ifosfamide, vincristine, actinomycin, with or without doxorubicin), radiotherapy and surgery for 6 to 8 months.

Maintenance chemotherapy included six 28-day cycles of 25 mg/m2 IV vinorelbine on days 1, 8 and 15 of each cycle and continuous daily oral 25 mg/m2 cyclophosphamide.

Clinical characteristics of the patients were similar between the groups. Incomplete resected embryona disease occurred in 67% of patients; 33% had alveolar disease; 21% were aged 10 years or older; and the most common primary tumor site was parameningeal (32%) followed by other sites (23%).

Researchers defined DFS as 5 years without tumor recurrence or mortality from any cause.

At 5 years, the DFS was 77.6% (70.6-83.2) among patients in the standard and maintenance therapy group compared with 69.8% (62.2-76.2) in the standard therapy only group, for a HR of 0.68 (95% CI, 0.45-1.02).

More patients treated with maintenance therapy achieved 5-year OS than patients who underwent standard therapy (86.5% vs. 73.7%; HR = 0.52; 95% CI, 0.32-0.86).

Toxicities were manageable among patients who underwent maintenance therapy. Twenty-five percent of patients experienced grade 3 or 4 febrile neutropenia. Grade 4 neurotoxicity occurred in 1.1% of patients.

Maintenance therapy led to fewer occurrence of anemia, febrile neutropenia, thrombocytopenia, and infectious episodes than occurred during standard treatment, Bisogno noted. Further, no cardiac, hepatic, gastrointestinal or renal toxicities were observed.

“The same approach is worthwhile to be investigated in other solid tumors of childhood,” Bisogno said. – by Melinda Stevens

Reference:

Bisogno G, et al. Abstract LBA2. Presented at: ASCO Annual Meeting; June 1-5, 2018; Chicago.

Disclosures: Bisogno reports a consultant/advisory role with Clinigen Group and travel expenses, accommodations or other expenses from Jazz Pharmaceuticals. Please see the abstract for all other authors’ relevant financial disclosures.