HIV remained undetectable after hematopoietic stem cell transplant
Up to 4.3 years after transplant, HIV DNA was not detected in the blood and rectal tissue among two patients with HIV who underwent hematopoietic stem cell transplantation for cancer, researchers reported at the 2013 International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention in Kuala Lumpur, Malaysia.
Researchers from Brigham and Women’s Hospital, Harvard Medical School and Massachusetts General Hospital in Boston conducted the study. The two patients had received reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation from wild-type CCR5 donors. The researchers collected peripheral blood mononuclear cells by leukapheresis from both patients and rectal tissue from one patient to quantify HIV DNA and perform viral co-culture from CD4+ T lymphocytes.
No HIV DNA was detected in any of the peripheral blood mononuclear cells from either patient, suggesting that the peripheral viral reservoir size decreased by 3 log10 to 4 log10. They also found no HIV p24 antigen in the CD4+ T cells, and there also was no HIV DNA detected in the rectal tissue.
For more information:
Henrich T. Abstract WELBA05. Presented at: 7th IAS Conference on HIV Pathogenesis, Treatment and Prevention; June 30-July 03, 2013; Kuala Lumpur, Malaysia.