February 27, 2021
2 min read

7 recent reports on pancreatic disorders

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Healio Gastroenterology presents the following reports on the most recent research on pancreatic disorders.

These reports include updates on pancreatic cancer, chronic pancreatitis and pancreatic cysts.

Acute pancreatitis, SARS-CoV-2 increase risk for disease severity

Patients with coexistent acute pancreatitis and SARS-CoV-2 infection had an increased risk for severe acute pancreatitis and worse clinical outcomes, according to study results.

Manu Nayar, MD, from Freeman Hospital in Newcastle, United Kingdom, and colleagues wrote that new data suggest the gastrointestinal tract and the pancreas appear to be target organs for SARS-CoV-2 because of the expression of the ACE2 receptor there. READ MORE

Study validates prediction model to differentiate chronic pancreatitis vs healthy cohort

Investigators identified and validated a human blood-metabolome prediction model that distinguished between patients with chronic pancreatitis and healthy individuals.

“Whether this biomarker has clinical value for diagnosing early stages of chronic pancreatitis or can be used to monitor disease progression needs further prospective studies,” M. Gordian Adam, MD, from the Metanomics Health GmbH, Berlin, Germany, and colleagues wrote in Gut. READ MORE

VIDEO: Healthy lifestyle key to pancreatic cancer prevention

In this exclusive video, Monique van Leerdam, MD, and Matthias Löhr, MD, PhD, discuss possible preventions for pancreatic cancer.

Löhr, from Karolinska Institutet in Sweden, said better digestive health is a key preventive measure for pancreatic cancer. Better digestive health is achieved through healthier lifestyle choices, including eating healthy, not smoking and drinking less alcohol, he said. READ MORE

VIDEO: Pancreatic cancer should be considered a ‘medical emergency’

In this exclusive video, Monique van Leerdam, MD, and Matthias Löhr, MD, PhD, discuss the need for increased awareness about pancreatic cancer.

Van Leerdam, from Leiden University in the Netherlands, said that although pancreatic cancer is not as high profile as other cancers, by 2030, it will be No. 2 in terms of cancer-related deaths. READ MORE

VIDEO: Early detection difficult in pancreatic cancer

In this exclusive video, Monique van Leerdam, MD, and Matthias Löhr, MD, PhD, discuss the need for better early detection of pancreatic cancer.

Van Leerdam, from Leiden University in the Netherlands, said there are currently programs in place for surveillance of patients at high-risk with MRI. However, early detection for the general population is much more difficult. READ MORE

Close follow-up needed in patients with pancreatic cysts

High incidence of malignant transformation in patients with pancreatic cysts confirms the need for close follow-up, according to a presentation at the American College of Gastroenterology Virtual Annual Scientific Meeting.

“The post-operative course of patients with surgically excised pancreatic cysts (PC) are limited. ... The current guideline recommendations on post-operative surveillance are variable and are based on variable quality of evidence,” Mohannad Abou Saleh, MD, Cleveland Clinic, said. “This prompted us to pursue this project with the aim to describe the post-operative course of PC patients and evaluate the rates and predictors of recurrences high risk and malignant transformation.” READ MORE

Changes in duodenal fluid microbiome profile seen in pancreatic cancer

Patients with pancreas ductal adenocarcinoma, compared with pancreatic cysts or normal pancreata, had changes in their duodenal fluid microbiome profiles, according to study results.

“Comparison of the microbial profiles of resected pancreatic cancer tissues with duodenal fluid revealed examples of concordance as well as discordance of bacterial and fungal genera consistent with the hypothesis that the main source of microbes within pancreatic tumors is the upper gastrointestinal tract with discordance possibly reflecting examples of hematogenous sources of bacteria,” Shiro Kohi, MD, from the departments of pathology, medicine, and oncology at The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, and colleagues wrote. READ MORE