Crohns & Colitis Congress
Crohns & Colitis Congress
January 30, 2020
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VIDEO: Patient-reported outcome system may help ‘drill down’ QOL issues after IPAA

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AUSTIN, Texas — In this exclusive video from Crohn’s & Colitis Congress, Edward L. Barnes, MD, MPH, assistant professor of medicine at the University of North Carolina at Chapel Hill, discusses the results of a study he and colleagues presented that showed how patients with recent pouchitis had significant reductions in specific areas of social, emotional and physical health.

To evaluate the connection between recently reported pouchitis and specific Patient-Reported Outcome Measurement Information System (PROMIS) domains – such as anxiety, fatigue and social role satisfaction – and health-related quality of life as assessed by Cleveland Global Quality of Life scale, Barnes and colleagues conducted a cross-sectional analysis of 118 patients who reported having an ileal pouch-anal anastomosis for ulcerative colitis.

More than half of the patients (n = 70) reported pouchitis in the previous 6 months. The researchers did not identify any significant differences in age, sex, race, or number of stages of IPAA between patients with and without recent pouchitis.

Patients with recent pouchitis were more likely to demonstrate higher levels of anxiety (53.8% vs. 48.5%), depression (52.2% vs. 46.9%), fatigue (55.8% vs. 47.8%), pain interference (54.4% vs. 48.1%), sleep disturbance (54.3% vs. 48.8%), and lower levels of social satisfaction (47.4% vs. 53.6%).

Barnes noted that the study also demonstrated that the PROMIS measures correlated with Global Quality of Life scale.

“This is important because that shows that we can use the PROMIS measures going forward in research studies and try to drill down on some more granular assessments of quality of life,” Barnes said. “Patients with pouchitis do show decreases in important domains of quality of life including pain, anxiety, depression, social satisfaction, and patients with pouchitis and patients that don’t have pouchitis showed important correlations with the more commonly used Cleveland Global Quality of Life Scale.”

Reference:

Barnes EL, et al. Poster 48. Presented at: Crohn’s and Colitis Congress; Jan. 23-25, 2020; Austin, Texas.