The Endocrine Society

The Endocrine Society

March 27, 2019
4 min watch
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VIDEO: FSH-blocking antibody could treat obesity, osteoporosis

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NEW ORLEANS — In this video exclusive, Mone Zaidi, MD, PhD, professor of medicine and director of the bone program at the Icahn School of Medicine at Mount Sinai, discusses his 2 decades of research on the role of pituitary hormones in the regulation of the skeleton, particularly in postmenopausal women.

Zaidi’s work has revealed that there may be more direct action by some hormones on bone loss in osteoporosis. Specifically, he said rising follicle-stimulating hormone (FSH) levels in the face of normal estrogen levels can lead to high rates of bone loss.

Preliminary studies in mice suggest that certain antibodies against FSH can minimize bone loss. Zaidi said this antibody can also contribute to body fat loss, with white fat being converted into more energy critical fat tissue. Due to this potential dual action, according to Zaidi, this could prove to be an effective treatment for obesity and osteoporosis in humans.

Watch the video for more.