Bariatric surgery associated with reduced psoriasis risk
Adults with obesity who underwent bariatric surgery were less likely to develop psoriasis vs. those who received usual care, according to findings reported in Obesity.
Cristina Maglio, MD, PhD, resident physician in rheumatology at the Sahlgrenska Academy Institute of Medicine at the University of Gothenburg, Sweden, and colleagues analyzed data from 1,991 patients who underwent vertical gastroplasty, gastric banding or gastric bypass surgery (mean age, 47 years; 29% men; mean baseline BMI, 42 kg/m²) and 2,018 patients with obesity who did not undergo surgery (mean age, 49 years; 29% men; mean baseline BMI, 40 kg/m²). The patients, all participants in the ongoing Swedish Obese Subjects study (recruited between 1987-2001), did not have psoriasis or psoriatic arthritis at baseline. Information about psoriasis and psoriatic arthritis diagnoses was retrieved through the Swedish National Patient Register and questionnaires.
During a median follow-up of 18.7 years for the surgery group and 18.1 years for controls, 174 patients developed psoriasis, including 46 patients who developed psoriatic arthritis. The incidence rate was lower among patients in the bariatric surgery group (71 vs. 103).
After adjustment for risk factors, the HR for developing psoriasis was 0.65 (95% CI, 0.47-0.89) in the surgery cohort. Additionally, smoking (HR = 1.75; 95% CI, 1.26-2.42) and a longer duration of obesity (HR = 1.28; 95% CI, 1.05-1.55) were each independently associated with psoriasis risk. There were no between-procedure differences in psoriasis risk.
“After stratifying the population according to the surgical procedure, only vertical banded gastroplasty was significantly associated with a lower incidence of psoriasis compared with conventional treatment,” the researchers wrote. “However, when comparing the three procedures among each other, they did not differ in terms of prevention of psoriasis.”
Researchers did not observe any association between bariatric surgery and psoriatic arthritis. – by Regina Schaffer
Disclosures: The authors report no relevant financial disclosures.