July 05, 2017
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High caffeine, coffee consumption reduces risk for low SHBG

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The risk for low sex hormone-binding globulin, a marker of risk for type 2 diabetes, may be reduced in women who consume large amounts of caffeine and coffee per day compared with women who consume less, according to findings published in Clinical Endocrinology.

Fabrice Bonnet, MD, PhD, of the department of endocrinology at Rennes University Hospital in France, and colleagues evaluated data from the E3N cohort study on 2,377 premenopausal and postmenopausal women (mean age, 57.3 years) without diabetes to determine the relationship between coffee and caffeine consumption and the risk for low plasma SHBG concentration. Participants completed questionnaires to report on diet (including coffee and caffeine consumption), lifestyle and medical conditions. Participants had a median SHBG value of 63.9 nmol/L.

The presence of low SHBG was inversely associated with caffeine (P for trend = .004) and coffee (P for trend = .01) consumption after adjustment for confounding factors. The risk for low SHBG was reduced in participants with the highest levels of total coffee intake ( 3 cups per day; OR = 0.69; 95% CI, 0.52-.092) and the highest levels of caffeine intake ( 265 mg per day; OR = 0.68; 95% CI, 0.5-0.94) compared with participants who consumed less coffee and caffeine. The risk for low SHBG was not significantly associated with decaffeinated coffee intake, and tea consumption was not associated with SHBG levels.

Significant associations between caffeine (P for trend = .005), total coffee (P for trend = .005) or caffeinated coffee intake (P = .04) and SHBG were observed in women with overweight only after stratification by BMI categories.

“In this large study ... high coffee and caffeine intakes were associated with a reduced risk of low SHBG, an established risk marker for [type 2 diabetes],” the researchers wrote. “The association was particularly marked among overweight and postmenopausal women, who are at higher risk of developing diabetes. Our results support the hypothesis that SHBG may partly explain the protective effect of coffee and caffeine against incident diabetes.” – by Amber Cox

Disclosures: The researchers report no relevant financial disclosures.