Diagnosed celiac disease may increase risk for hip, other bone fractures
Clinically diagnosed celiac disease appears to be linked to an increased risk for hip fractures and other types of bone fractures, according to recent findings.
In the systematic review and meta-analysis, researchers queried four electronic databases for studies pertaining to celiac disease and the prevalence of bone fractures. Results were collected from eligible studies by two investigators and a random effects meta-analysis was used to pool the study-specific findings. Six studies were included in the systematic review and 14 were included in the meta-analysis.
Based on the meta-analysis of the case-control and cross-sectional studies, the researchers found that patients with clinically diagnosed celiac disease had almost twice the prevalence of bone fractures compared with those without diagnosed celiac disease. The meta-analysis of prospective studies reveled that baseline celiac disease was related to a 30% increase in bone fracture of any kind and a 69% increase in hip fracture risk.
“The findings of our meta-analysis suggest that celiac disease and bone fractures co-occur and that diagnosed celiac disease is associated with an increased risk of fractures,” the researchers wrote. “However, further research would be needed to determine whether this association is specific to particular parts of the skeleton or types of fractures, and whether unrecognized celiac disease, marked by elevated circulating celiac disease-specific antibodies, is associated with the risk of bone fractures.”
Disclosure: The study was funded in part by the Academy of Finland, the Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital and Seinäjoki Central Hospital and the Sigrid Juselius Foundation.