January 21, 2013
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NHANES: BPA linked to endothelial dysfunction in US children

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Recent findings from the National Health and Nutrition Examination Survey suggest that endothelial dysfunction is another adverse effect of bisphenol A, a chemical used to manufacture polycarbonate resin. The chemical has been labeled an endocrine disruptor by The Endocrine Society and the topic of several investigations in recent literature.

“While our cross-sectional study cannot definitively confirm that [bisphenol A] contributes to heart disease or kidney dysfunction in children, together with our previous study of BPA and obesity, this new data adds to already existing concerns about BPA as a contributor to cardiovascular risk in children and adolescents,” researcher Leonardo Trasande, MD, MPP, of NYU School of Medicine and NYU Langone Medical Center, said in a press release. “It further supports the call to limit exposure to [bisphenol A] in this country, especially in children. Removing it from aluminum cans is probably one of the best ways we can limit exposure. There are alternatives that manufactures can use to line aluminum cans.”

Trasande and colleagues examined data from 710 children in the 2009-20120 NHANES with urinary bisphenol A (BPA) measurements and first morning urine samples with creatinine values.

According to data, patients with the highest quartile of urinary BPA compared with the lowest quartile of urinary BPA demonstrated a significant 0.91-mg/g higher albumin-to-creatinine ratio. Additional data indicate that for each log unit increase in urinary BPA when the multivariable model was delivered in place of continuous measures, researchers saw a significant 0.28-mg/g albumin-to-creatinine ratio increase.

Trasande and colleagues suggest that an association exists between BPA exposure and low-grade albuminuria, consistent with previous findings. They conclude that further research is necessary to examine potential cardiovascular disease related to environmental chemicals.

Disclosure: The researchers report no relevant financial disclosures.