Top stories in dermatology: IMIDs in psoriasis, Dupixent for keloids
In a top Healio Dermatology story, preliminary findings from Emma Guttman-Yassky, MD, PhD, demonstrate a novel use of dupilumab for managing chronic keloids with reductions in skin fibrosis and keloidal scarring, which may suggest a potential underlying Th2 pathogenesis in keloid formation.
In another popular story, patients with psoriasis have five times the risk for immune-mediated inflammatory diseases, according to researchers from the University of Copenhagen.
Continue reading for additional top updates in dermatology.
Risk for immune-mediated inflammatory diseases five times higher in psoriasis
Psoriasis was associated with a higher risk for 11 of the 16 immune-mediated inflammatory diseases studied and a five times higher risk for inflammatory diseases overall. Read more.
Mount Sinai researcher explores keloid response to Dupixent
“This is really a paradigm change because when you think of keloids, people think they are an abnormal fibroblast growth, an abnormal wound healing. No one thinks it is an inflammatory condition. That is completely a game changer,” Guttman-Yassky, of the department of dermatology and laboratory of inflammatory skin diseases at Icahn School of Medicine at Mount Sinai, told Healio. Read more.
Melanoma testing: Progress in practice
In my practice, I have found noninvasive gene expression testing is useful in the many cases in which the lesion falls somewhere in between obviously benign and highly suspicious. These are the patients for whom objective genomic testing is particularly helpful. Surgical biopsies remain the standard of care for melanoma diagnosis; however, there are numerous instances when we want to avoid unnecessary cutting. Read more.
Patient decisions on dysplastic nevus management vary based on information framing
How clinicians frame the information presented to patients about dysplastic nevi diagnosis and management affects patient decision-making on surgical options, according to researchers in Journal of the American Academy of Dermatology. Read more.