Disclosures: Vidal-Petiot reports she received nonfinancial support and personal fees from Servier outside the submitted work. Please see the study for all other authors’ relevant financial disclosures.
April 08, 2021
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Patients with chronic coronary syndromes, diabetes may be at elevated risk for CV events

Disclosures: Vidal-Petiot reports she received nonfinancial support and personal fees from Servier outside the submitted work. Please see the study for all other authors’ relevant financial disclosures.
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Nearly 30% of patients with chronic coronary syndromes have diabetes and are at an increased risk for adverse CV outcomes, according to a study published in the European Journal of Preventive Cardiology.

“Diabetes was linked with worse outcomes, even in areas with the lowest prevalence. In Europe, for instance, diabetes was linked with a 29% greater risk of the combined outcome of heart attack, stroke or cardiovascular death. This indicates that management of these very high-risk patients with heart disease and diabetes should be improved. Each country needs to identify these patients and provide tailored educational and prevention programs,” Emmanuelle Vidal-Petiot, MD, PhD, associate professor at Bichat-Claude Bernard Hospital, Paris, said in a press release.

Alert on heart monitor
Source: Adobe Stock

Researchers conducted an analysis of 32,694 patients from the CLARIFY registry with chronic coronary syndromes from 45 countries. Among the cohort, 29% had diabetes.

The researchers identified patients with more than one of the following criteria as having chronic coronary syndromes: MI, evidence of coronary stenosis greater than 50%, proven symptomatic myocardial ischemia and a prior revascularization procedure.

In a multivariable-adjusted model, researchers reported that among patients with chronic coronary syndromes, diabetes was associated with increased risks for CV death, MI or stroke (adjusted HR = 1.28; 95% CI, 1.18-1.39), all-cause death (aHR = 1.38; 95% CI, 1.27-1.5), CV death (aHR = 1.39; 95% CI, 1.25-1.54), MI (aHR = 1.26; 95% CI, 1.1-1.43), stroke (aHR = 1.29; 95% CI, 1.09-1.52), HF hospitalization (aHR = 1.15; 95% CI, 1.03-1.28) and coronary revascularization (aHR = 1.14; 95% CI, 1.04-1.25).

“Obesity and lack of exercise are common risk factors for both diabetes and heart disease, and our results highlight the urgent need to improve nutrition and raise activity levels globally,” Vidal-Petiot said in the release.