January 25, 2020
2 min read

Top stroke news of 2019: ISC updates, recurrent stroke prevention and more

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Healio and Cardiology Today compiled a list of the most-read articles in stroke research published in 2019.

This year, Healio readers were most interested in new data presented at the International Stroke Conference, recurrent stroke risk after treatment with cilostazol, dabigatran and rivaroxaban, and more.


Low LDL, triglycerides increase stroke risk in women

Women with LDL levels below 70 mg/dL and low triglyceride levels had increased risk for hemorrhagic stroke, according to a study published in Neurology. Read more


Adding cilostazol to antiplatelet therapy reduces recurrent ischemic stroke risk

Stroke survivors who had cilostazol added to aspirin or clopidogrel had reduced risk for recurrent ischemic stroke compared with patients taking aspirin or clopidogrel alone, according to results from the CSPS.com study presented at the International Stroke Conference. Read more


ANNEXA-4: Andexanet alfa successfully reverses factor Xa inhibitor effects

Andexanet alfa reversed the anticoagulation effects of factor Xa inhibitors in most patients with acute major bleeding caused by a factor Xa inhibitor, according to the full data from the ANNEXA-4 study presented at the International Stroke Conference. Read more


Dabigatran not superior to aspirin for prevention of recurrent stroke

In a study published in The New England Journal of Medicine, there was no significant difference between dabigatran and aspirin in preventing recurrent stroke in patients with an embolic stroke of undetermined source. Read more


Artificially sweetened beverages increase risk for stroke in women

Adults who had high intake of artificially sweetened beverages had increased risks for stroke, CHD, small artery occlusion ischemic stroke and all-cause mortality, according to a study published in Stroke. Read more


Antiplatelet therapy appears safe after stroke due to intracerebral hemorrhage

Antiplatelet therapy appears safe to use for secondary prevention in patients who had a stroke due to intracerebral hemorrhage, according to results of the RESTART trial presented at the European Stroke Organization Conference. Read more


COMPASS: Low-dose rivaroxaban plus aspirin confers reduced embolic stroke risk

According to new data from the COMPASS trial, patients with systemic atherosclerosis assigned low-dose rivaroxaban plus aspirin had reduced risk for cardioembolic stroke and embolic stroke of undetermined origin compared with patients assigned aspirin alone. Read more



Alirocumab may reduce stroke risk without increasing odds of hemorrhage

New data from the ODYSSEY Outcomes trial show that alirocumab is effective at reducing risk for any stroke without increasing risk for hemorrhagic stroke. Read more


Intensive BP lowering reduces brain bleeds in ischemic stroke

Utilizing intensive BP lowering safely reduced intracerebral hemorrhage in patients with acute ischemic stroke, according to data from the ENCHANTED trial presented at the International Stroke Conference. Read more


Aspirin, rivaroxaban similar for recurrent stroke prevention in certain patients

In patients with embolic stroke of undetermined source and carotid atherosclerosis, aspirin and rivaroxaban were equally effective at preventing recurrent stroke, but aspirin was safer, according to new data from the NAVIGATE ESUS trial. Read more


Stroke risk increases after electrical LAA isolation

Electrical isolation of the left atrial appendage increased the risk for stroke, which can be reduced with left atrial appendage occlusion or uninterrupted oral anticoagulation, according to a study published in the Journal of the American College of Cardiology. Read more


DAPT may offer greatest benefit 21 days after minor stroke, TIA

The benefit of dual antiplatelet therapy after high-risk transient ischemic attack or minor ischemic stroke was limited to the first 21 days after the event, according to a pooled analysis of the CHANCE and POINT trials published in JAMA Neurology. Read more


General anesthesia confers less disability 3 months after thrombectomy for stroke vs. sedation

Protocol-based general anesthesia was linked to less disability at 3 months compared with procedural sedation among patients with acute ischemic stroke in the anterior circulation who underwent thrombectomy, according to a systematic review and meta-analysis published in JAMA. Read more