Corin levels associated with BP during pregnancy
Corin may be a biomarker to determine women who are at high risk for an adverse pregnancy outcome, according to a study published in Circulation.
“We show for the first time that the change in corin content from early to late pregnancy is related directly to resting BP levels in late pregnancy, suggesting that maternal corin content may represent a novel target in the ongoing investigation of useful biomarkers for determining women at high risk of adverse pregnancy outcome,” Mark B. Badrov, PhD, postdoctoral fellow at the Institute of Exercise and Environmental Science at Texas Health Presbyterian Hospital Dallas, and colleagues wrote.
Hypertension during pregnancy
Researchers analyzed data from 44 women (mean age, 29 years) who had singleton, full-term pregnancies, did not smoke and were free from disease. Women were categorized as the following: low-risk normal pregnancy (n = 23), high risk yet normal pregnancy (n = 13) and gestational hypertension after late pregnancy testing (n = 8).
Tests were conducted before pregnancy, 4 to 8 weeks into pregnancy, 32 to 36 weeks into pregnancy and 6 to 10 weeks after delivery to measure heart rate, BP, serum corin and muscle sympathetic nerve activity.
Compared with corin levels before pregnancy, levels were unchanged during early pregnancy, increased during late pregnancy (P < .001) and returned to before pregnancy levels after delivery. Corin level changes from early to late pregnancy were greater in women who developed gestational hypertension compared with those with low-risk normal pregnancies (971 pg/mL vs. 486 pg/mL; P < .05).
Systolic BP before pregnancy did not differ between all groups. Diastolic BP and mean arterial BP was higher in women with gestational hypertension compared with those with low-risk normal pregnancies (P < .05 for both). All groups had increases in systolic BP and mean arterial BP from early to late pregnancy compared with early pregnancy (P < .05 for all vs. early), which then returned to before pregnancy levels after delivery. Diastolic BP in women with gestational hypertension decreased during early pregnancy (P < .05), increased from early pregnancy to late pregnancy (P < .05) and returned to before pregnancy levels postpartum.
All groups had similar indices of muscle sympathetic nerve activity before pregnancy. During late pregnancy, burst incidence, burst frequency and total muscle sympathetic nerve activity increased (P < .05 for all) and returned to before pregnancy levels postpartum. Women with gestational hypertension had greater indices of muscle sympathetic nerve activity during early and late pregnancy compared with those with high-risk normal pregnancy and low-risk normal pregnancy (P < .05 for all).
Associations with corin
Changes in corin from early to late pregnancy were associated with systolic BP (R = 0.513; P < .001), diastolic BP (R = 0.454; P < .01) and mean arterial BP (R = 0.551; P < .001) during late pregnancy.
Early pregnancy levels of burst incidence (R = 0.576; P < .001), burst frequency (R = 0.614; P < .001) and total muscle sympathetic nerve activity (R = 0.606; P < .001) were associated with changes in corin levels from early to late pregnancy.
“Fundamentally, [gestational hypertensive disorders] reflect an inherent failure in properly regulating arterial BP homeostasis throughout pregnancy,” the researchers wrote. “Our present findings demonstrating the unique involvement of corin in neurocirculatory control throughout pregnancy offers an exciting new take on an enigmatic disease.” – by Darlene Dobkowski
Disclosure s : The authors report no relevant financial disclosures.