March 16, 2017
1 min read
Save

Good cardiorespiratory fitness decreases risk for nonfatal MI, HF in men

You've successfully added to your alerts. You will receive an email when new content is published.

Click Here to Manage Email Alerts

We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com.

Cardiorespiratory fitness was inversely associated with acute nonfatal MI and HF risk in a cohort of men, according to new findings.

“[CV] fitness is an important and modifiable risk factor associated with mortality,” Hassan Khan, MD, PhD, of Emory University, and colleagues wrote. “Multiple studies have demonstrated a consistent, inverse association between cardiorespiratory fitness and mortality even after adjustment for traditional risk factors. However, whether these associations persist in relation to nonfatal [CV] events has not been evaluated before.”

Khan and colleagues measured cardiorespiratory fitness in Finnish men (n = 2,089; aged 42 to 61 years) using a respiratory gas exchange analyzer to assess maximal oxygen uptake.

During follow-up (mean, 19.1 years), 522 nonfatal acute MI events, 198 acute all-cause nonfatal stroke events and 221 nonfatal HF events were recorded.

After adjustments for CV risk factors, a 1-metabolic equivalent increase in cardiorespiratory fitness was associated with a decreased risk for nonfatal MI (HR = 0.93; 95% CI, 0.88-0.97) nonfatal stroke (HR = 0.94; 95% CI, 0.87-1.01) and nonfatal HF event (HR = 0.84; 95% CI, 0.78-0.91).

When cardiorespiratory fitness was added to a conventional CVD risk score, there was significant improvement in discrimination for both nonfatal MI (change in C index = 0.015; 95% CI, 0.01-0.02) and HF (change in C index = 0.04; 95% CI, 0.01-0.06) and in reclassification for nonfatal MI (change in category free net reclassification index = 0.27; 95% CI, 0.13-0.42; P < .01) and for nonfatal HF (change in category free net reclassification index = 0.88; 95% CI, 0.53-1.24; P < .01)).

“Although the causal nature of these associations remains to be investigated, it is likely that higher levels of [cardiorespiratory fitness] improve [CV] risk profile, thereby decreasing the risk of future CVD events,” the researchers wrote. “Several physiological and metabolic mechanism underpin the association of low [cardiorespiratory fitness] with increased risk of CVD. Lower levels of physical activity are associated with endothelial dysfunction which contributes to preclinical atherosclerosis. Physical inactivity with poor [cardiorespiratory fitness] leads to elevated levels of [BP] and serum lipids, insulin resistance and obesity, all of which predispose to the development of CVD.” – by Cassie Homer

Disclosure: The researchers report no relevant financial disclosures.