January 11, 2016
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CVD mortality risk increasing for US adults with HIV

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Proportionate CVD mortality more than doubled among HIV-infected adults in the United States between 1999 and 2013, according to study findings published in The American Journal of Cardiology.

Matthew J. Feinstein, MD, of Northwestern University Feinberg School of Medicine, and colleagues assessed patterns of CVD mortality for HIV-infected adults in comparison with general and inflammatory polyarthropathy populations using the CDC WONDER online database. All participants were aged 25 years or older.

Matthew J. Feinstein

According to the findings, although total mortality in the HIV-infected population decreased from 15,739 to 8,660 between 1999 and 2013, proportionate CVD mortality increased from 1.95% to 4.62%, particularly in men (P < .0001). During the same period, proportionate CVD mortality decreased for the general and inflammatory polyarthropathy populations. Feinstein and colleagues also reported that for HIV-infected adults, mortality caused by ischemic heart disease tripled from 0.8% in 1999 to 2.5% in 2013. In the general population, however, ischemic heart disease mortality decreased from 22.8% to 14.6% during the same period.

In addition, the researchers observed that hypertensive heart and renal diseases, as well as pulmonary circulatory diseases, also were common causes of CVD-related death in the HIV-infected population.

“The results of this study underscore the emerging need for enhanced CVD risk prediction and prevention in the HIV-infected population. Traditional [CHD] risk prediction models, such as the Framingham risk score, may provide inadequate discrimination and be poorly calibrated in the HIV-infected population in light of the elevated HIV-related MI risks that may differ from traditional risk factors,” Feinstein and colleagues wrote. – by Tracey Romero

Disclosure: The researchers report no relevant financial disclosures.