July 25, 2011
1 min read

High, low BMI resulted in significant risk for deep intracerebral hemorrhage

Biffi A. Stroke. 2011;doi:10.1161/strokeaha.111.617225.

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Patients with low or high extremes of BMI were at increased risk for having a deep intracerebral hemorrhage. No association was reported on lobar intracerebral hemorrhage, however.

The single-center, prospective study involved 384 consecutive patients with intracerebral hemorrhage (ICH) — 196 with deep and 188 with lobar ICH — and 388 controls enrolled during a 6-year period. Researchers used CT to determine ICH characterization and patients’ height and weight to calculate BMI. Low BMI was defined as less than 18.5 kg/m² and high BMI was more than 30 kg/m².

Overall, patients with either low (OR=1.76; P=.011) or high BMI (OR=1.75; P=.013) were at increased risk for deep ICH, with the following characteristics associated with risk in univariate analysis: age, sex, hypertension, CAD, diabetes, hyperlipidemia and alcohol consumption of more than 3 oz per day. Neither univariate nor multivariate analysis revealed either BMI extremes to be linked with lobar ICH. The association with ICH was particularly prominent in men who had an OR of 2.85 (P=.041) vs. women who did not have an association (OR=0.89; P=.54).

“Our results suggest that BMI differentially influences risk of lobar and deep ICH, consistent with the hypothesis that BMI influences specific vascular pathologies that lead to ICH,” the researchers wrote. “In particular, these findings are most likely related to biological differences between cerebral amyloid angiopathy-related lobar ICH and hypertensive deep ICH.”

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