Perspective from Carina Venter, PhD, RD
Disclosures: The authors report no relevant financial disclosures.

May 13, 2022
4 min read

Mode, length of labor impact odds for food sensitization among infants

Perspective from Carina Venter, PhD, RD
Disclosures: The authors report no relevant financial disclosures.

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Vaginal delivery was associated with increased risk for food sensitization in infancy, with longer labor durations also promoting food sensitization development, according to a study published in Annals of Allergy, Asthma & Immunology.

This relationship between vaginal delivery and food sensitization remained consistent even when the number of siblings was considered, the researchers said.

woman in labor
Source: Adobe Stock

“The potential effect of delivery mode on the risk of childhood allergic disease development remains unclear, and the current evidence is conflicting,” Tetsuhiro Sakihara, MD, of the department of pediatrics at Heartlife Hospital in Nakagusuku, Okinawa, Japan, told Healio.

While some reports have indicated that caesarean delivery can elevate the risk for food sensitization and food allergy when compared with vaginal delivery, others have found no such associations, Sakihara said.

Tetsuhiro Sakihara

“Furthermore, maternal and infant stress during labor may affect prenatal immune development by reducing naive regulatory T-cell numbers, but little is known about the relationship between labor duration, which can be indicative of stress exposure, and the risk of food sensitization,” Sakihara said.

To bridge these gaps in the literature, Sakihara continued, the researchers conducted the study to assess whether delivery mode and labor duration affect the risk for developing food sensitization in infancy.

The study’s design and results

The researchers analyzed data from the Strategy for Prevention of Milk Allergy by Daily Ingestion of Infant Formula in Early Infancy (SPADE) study, which involved four hospitals in Okinawa between Jan. 1, 2017, to Aug. 31, 2019.

The cohort included 462 infants, with 353 delivered vaginally and 109 delivered via cesarean section, although the researchers only had data on the duration of labor for 325 infants delivered vaginally and 104 delivered via cesarean section.

Between the first and second month, infants were randomly assigned to a group that ingested 10 mL or more of cow’s milk formula (CMF) each day or to a group that avoided CMF, both through age 6 months.

Also, oral food challenges were performed with 20 mL of CMF when aged 1 month, 50 mL when aged 3 months and 100 mL when aged 6 months. Skin prick testing was conducted for hen’s egg, cow’s milk, wheat and soy when the infants were aged 3 months and 6 months.

The infants born through vaginal delivery tended to have a higher gestational age, with a higher proportion of them not ingesting any CMF in their first 3 days of life. Also, they had a lower parental age at delivery and lower maternal BMI before pregnancy.

At age 6 months, the infants born through vaginal delivery had significantly higher incidences of food sensitization (P = .01) and hen’s egg sensitization (P = .01) as indicated by one or more positive SPT reaction compared with those born through cesarean delivery.

The researchers, however, did not find any significant differences in sensitization incidences to cow’s milk, wheat or soy.

Overall, 1.5% of the infants had developed cow’s milk allergy by age 3 months, including 1.1% of those delivered vaginally and 2.6% of those with cesarean delivery. By age 6 months, the overall proportion was 4.1%, with 4.2% among those delivered vaginally and 3.7% of those with cesarean delivery.

“The incidence of food sensitization development by 6 months of age was significantly higher in vaginal delivery-born infants than in CS-born infants,” Sakihara said.

“This positive association between vaginal delivery and food sensitization development remained statistically significant even after adjusting for other parental, perinatal and environmental factors,” he continued.

Infants with food sensitization experienced significantly longer labor durations with a median of 5.7 hours (interquartile range [IQR], 2.7-10.1), compared with those without food sensitization, who experienced a median of 4.5 hours (IQR, 1.1-8.2; P = .01).

The researchers said they found a significant association between longer labor durations and a higher proportion of infants with food sensitization as well (P = .008).

Infants born through vaginal delivery further experienced an adjusted odds ratio of 2.75 (95% CI, 1.34-5.64) for hen’s egg sensitization and 1.98 (95% CI, 0.72-5.46) for cow’s milk sensitization.

Additionally, the infants with hen’s egg sensitization experienced significantly longer labor duration, with a median of 5.7 hours (IQR, 3.4-10.5) compared with those without hen’s egg sensitization, who had a median of 4.5 hours (IQR, 1.1-8.2; P = .005).

There was no significant difference in the duration of labor between those infants who had cow’s milk sensitization (median, 4.5 hours; IQR, 2.3-10.5) and those who did not (median, 4.7 hours; IQR, 1.9-9).

Among the 169 infants who did not have any siblings, there was no significant difference in the duration of labor between infants with food sensitization (median, 9.1 hours; IQR, 4.9-14.3) and those without (median, 9.1 hours; IQR, 4.7-16.1).

However, among infants with one or more siblings, those with food sensitization had significantly longer labor (median, 4.2 hours; IQR, 2.4-6.1) compared with those who did not have food sensitization (median, 3.1 hours; IQR, 0-5.3; P = .02).

Next steps

Although they did not analyze why allergic diseases developed in these infants, the researchers suggested influences including exposure to the maternal vaginal microbiome, indications for cesarean delivery and maternal dietary factors and gut microbiome during pregnancy.

“Vaginal delivery with longer labor duration may promote the development of food sensitization and may be considered as one of the important risk factors of food sensitization developing,” Sakihara said.

Also, the researchers noted the possibly temporary nature of the effects of the mode of delivery on the diversity and colonization of an infant’s gut microbiota, which may be affected by antibiotic exposure, early skin-to-skin contact, breastfeeding and the introduction of complementary foods.

The researchers suggested that these confounders should be considered in future research.

“Additional prospective cohort studies are needed to assess the relationship between labor duration and food sensitization or food allergy development in larger community-based populations over longer follow-up periods,” Sakihara said.

For more information:

Tetsuhiro Sakihara, MD, can be reached at