Investigators found oxycodone is removed during hemodialysis. However, not enough is removed to require additional dosing in patients with ESRD. According to findings published in Nephrology Dialysis Transplantation, the pharmacokinetics of oxycodone and the absence of unconjugated active metabolites demonstrate oxycodone can be used at the usual dosage.
Researchers used a cross-over design to administer single doses of oxycodone/naloxone in nine patients with ESRD on the day of dialysis and on a day between dialysis sessions. Investigators used a liquid chromatography–tandem mass spectrometry system to determine plasma, dialysate and urine concentrations of oxycodone, naloxone and patients’ metabolites up to 48 hours post-dosing.
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