Mycophenolic acid C12 to be associated with the 12-hour area under the curve, and linked to renal flare, infection and anemia, according to findings published in Nephrology Dialysis Transplantation.
“There is emerging preliminary data on the level of mycophenolic acid exposure that is associated with favorable response to induction immunosuppression for lupus nephritis,” Desmond Y. Yap, MD, of the of , Department of Medicine at the University of Hong Kong and colleagues wrote. “In contrast, there is little data on the relationship between MPA exposure and disease status or drug-induced adverse events such as marrow suppression and infection during the maintenance phase.”researchers evaluated 88 individuals with biopsy-proven, stable lupus nephritis who had undergone continuous treatment with prednisolone and mycophenolate mofetil as both induction and maintenance immunosuppressive therapy. Additionally, eligible patients had responded favorably to treatment, with more than 12 months elapsed between the start induction immunosuppression and the last incidence of active nephritis. prednisolone 0.8 mg/kgday and mycophenolate mofetil 1 g twice per day. At approximately 6 months, the prednisolone dose was decreased to 7.5 mgday, and at 12 months, it was decreased to 57.5 mgday. ycophenolate mofetil at a target dose of 1,000 mg twice daily for 6 months, 750 mg twiceday between month 7 and month 12, and 500750 mg twice day in the second year of treatment.
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